散结镇痛胶囊联合去氧孕烯炔雌醇片治疗轻型子宫内膜异位症的疗效和安全性

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Abstract Objective This research aims to investigate the efficacy and safety of the Sanjie Zhentong capsule combined with desogestrel and ethinylestradiol tablets in the treatment of mild endometriosis.Methods From December 2013 to May 2017, in China Emergency General Hospital and Beijing Municipal Corps Hospital of Chinese People's Armed Police Force, a total of 90 patients with mild endometriosis without surgical indications were randomly allocated into either the Study Group (n=45) or the Control Group (n=45). The study group took Sanjie Zhentong capsules orally from the first day of menstruation, 1.6g each and three times per day. Simultaneously, one desogestrel and ethinylestradiol tablet was taken orally in the evening from the first day of menstruation for 21 days. A new cycle was started on the eighth day of withdrawal.The research lasted for six consecutive months. The control group was given only desogestrel ethinylestradiol tablets, and the method was the same as that of the study group. The patients were examined before and after treatment, including gynecological examination, visual analogue scale (VAS) score, B ultrasound, electrocardiogram, liver and kidney function, coagulation function, and CA125.Results The cure rate of the study group was 73.3%, and that of the control group was 31.1%, the difference was statistically significant (P< 0.05); The total effective rate of the study group was 97.8%, and that of the control group was 82.2%, the difference was statistically significant (P< 0.05); The score of VAS in the study group was (1.9±1.1) and that of in control group was (2.7±1.8) after treatment, the difference was statistically significant (P< 0.05); The value of serum CA125 in the study group was (19.62±11.13)U/ml, and that of in control group was (24.78±13.21)U/ml, the difference was statistically significant (P<0.05).Conclusions Sanjie Zhentong capsule combined with desogestrel and ethinylestradiol tablets is safe and effective in treating mild endometriosis.

Key words： Sanjie Zhentong capsule desogestrel and ethlinylestradiol tablets endometriosis

Received: 10 April 2021

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	ZHU Xinyu
	MAO Yuefang
	XING Lina
	ZHANG Yunhe

Cite this article:

ZHU Xinyu,MAO Yuefang,XING Lina等. Clinical study on combined Sanjie Zhentong capsule and desogestrel and ethlinylestradiol tablets in treatment of mild endometriosis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(9): 773-775.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2021/V32/I9/773

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