β-catenin与Lgr5在胃癌进程中的表达及其意义

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Abstract Objective To find out about the expressions and significance of β-catenin and Lgr5 in normal gastric mucosa, chronic superficial gastritis, chronic atrophic gastritis and gastric cancer. Methods A total of 105 inpatients and outpatients treated in our hospital between March 2014 and June 2015 were selected, including 23 cases of normal gastric mucosa, 25 cases of chronic superficial gastritis, 27 cases of chronic atrophic gastritis and 30 cases of gastric cancer. Immunohistochemistry was used to detect the expressions of β-catenin and Lgr5. Immunoreactivity was semi-quantitatively scored based on the percentage of positive cells and intensity of immunostaining. Results The positive rate of β-catenin was 8.7% in normal gastric mucosa, 28.0% in chronic superficial gastritis, 59.3% in chronic atrophic gastritis and 83.3% in gastric cancer, respectively, so the difference was statistically significant (P<0.05). The positive expression rate of Lgr5 was 13.0% in normal gastric mucosa, 32.0% in chronic superficial gastritis, 66.7% in chronic atrophic gastritis and 86.7% in gastric cancer, respectively. The difference was also of statistical significance (P<0.05). Conclusions β-catenin and Lgr5 are important markers to detect abnormal activation of Wnt/β-catenin signal pathway during the occurrence and development of gastric cancer.

Key words： β-catenin Lgr5 chronic atrophic gastritis gastric cancer

Received: 03 June 2021

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	Articles by authors
	ZHENG Yanmin
	LIU Jiping
	ZHOU Xiaopin
	ZHAO Hongyan
	YU Meina
	NIU Haiyan

Cite this article:

ZHENG Yanmin,LIU Jiping,ZHOU Xiaopin等. Expressions and significance of β-catenin and Lgr5 in the progression of gastric cancer[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(10): 836-839.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2021/V32/I10/836

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