血清1,25-二羟维生素D<sub>3</sub>水平与结直肠腺瘤的相关性

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Abstract Objective To investigate the association between serum levels of1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) and colorectal adenomas. Methods Two hundred and eighteen cases of colorectal polyps admitted to our hospital between February 2016 and December 2020 were included in this study. According to pathological results, they were divided into the non-adenomatous group(n=104), adenomatous group(n=69), low-grade intraepithelial neoplasia group(n=25), and high-grade intraepithelial neoplasia group(n=20). Serum 1,25(OH)₂D₃ levels were tested. Results The serum level of 1,25(OH)₂D₃ was the highest in the non-adenomatous group(32.48±3.54), followed by the adenomatous group(29.48±3.35), the low-grade intraepithelial neoplasia group(29.40±3.41) and the high-grade intraepithelial neoplasia group(28.65±2.11). The serum levels of 1,25(OH)₂D₃ in the other three groups were significantly lower than in the non-adenomatous group. There were 20 cases (19.23%), 39 cases (56.52%), 13 cases (52.00%) and 7 cases (35.00%) with low serum 1,25(OH)₂D₃ levels in the above four groups respectively. There was statistically significant difference between the four groups. After adjustment for confounding factors,such as age, smoking, alcohol consumption, diabetes, osteoporosis, and BMI≥25, multivariate logistic regression analysis indicated that odds ratio between 1,25(OH)₂D₃ deficiency and colorectal adenomas was 5.774 (95%CI, 2.837-11.751). Conclusions The pathological types of colonic polyps are related to vitamin D deficiency, which may be a risk factor for colorectal adenomas and intraepithelial neoplasia.

Key words： serum 1, 25-dihydroxyvitamin D₃ colorectal adenomas intraepithelial neoplasia association

Received: 15 June 2021

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