血清总胆汁酸及N末端B型钠尿肽原在慢性心力衰竭合并2型糖尿病患者预后评估中的应用价值

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Abstract Objective To study the applicability of serum total bile acid (TBA) and N terminal pro B type natriuretic peptide (NT-proBNP) in the assessment of prognosis of patients with chronic heart failure (CHF) complicated with type 2 diabetes (T2DM). Methods A total of 146 CHF patients hospitalized in Beijing Electric Power Hospital between October 2019 and June 2020 were selected and divided into the observation group (n=87) and control group (n=59) according to complications with T2DM. The levels of TBA and NT-proBNP in each group were detected, and the clinical value of TBA, NT-proBNP, and their combined detection in the prognosis assessment of CHF patients with T2DM was analyzed respectively by the ROC curve. Results Compared with the control group, the levels of TBA and NT-proBNP in the observation group were significantly increased (P<0.01). Spearmen grade correlation analysis showed that the cardiac function grade in the observation group was positively correlated with TBA levels (r_s=0.633, P<0.01). Pearson correlation analysis showed that the level of TBA in the observation group was positively correlated with the level of NT-proBNP (r=0.539, P<0.01). ROC curve analysis showed that the area under the ROC curve with serum TBA+NT-proBNP combined detection was significantly larger than that of TBA and NT-proBNP used alone(0.942 vs. 0.728 and 0.912, P<0.05). Conclusions Serum TBA levels are significantly increased in CHF patients with T2DM and are positively correlated with cardiac function classification. Serum TBA and NT-proBNP levels can help predict the prognosis of CHF patients with T2DM, and combined detection is better.

Key words： total bile acid NT-proBNP heart failure diabetes ROC curve

Received: 22 April 2021

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	YU Hong
	ZHANG Jiao
	ZHANG Lu
	JING Limin

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YU Hong,ZHANG Jiao,ZHANG Lu等. Applicability of serum total bile acid and NT-proBNP levels in prognostic evaluation of patients with chronic heart failure and type 2 diabetes[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(11): 977-980.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2021/V32/I11/977

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