肿瘤标志物AFP、CEA、SF及β<sub>2</sub>-MG检测对冠心病和高血压病的诊治及预后判断价值

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Abstract Objective To investigate the changes and clinical significance of serum levels of alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), serum ferritin (SF) and β₂-microglobulin (β₂-MG) in patients with coronary heart disease (CHD) and hypertension.Methods From among the military outpatients who had visited Beijing Municipal Corps Hospital of Chinese People’s Armed Police Force between February 2017 and March 2019, 40 CHD patients (CHD group), 40 with hypertension (HTN group), and 40 with both CHD and hypertension (CHD and HTN group) were selected as the subjects, while another 40 healthy people served as the control group. The fasting venous blood of the four groups was tested. The levels of serum AFP, CEA, SF and β₂-MG in the four groups were detected and compared. The positive detection rates of serum SF and β₂-MG in the CHD group, HTN group and CHD and HTN group were recorded.Results There was no statistically significant difference in levels of AFP or CEA between the three groups and the control group (P>0.05). However, there was statistically significant difference in levels of β₂-MG and SF between the HTN group [(3.60±1.83)ng/mL, (202.96±99.06)ng/mL], CHD group [(3.41±1.31)ng/mL, (200.84±103.29)ng/mL], CHD and HTN group [(3.63±1.82)ng/mL, (207.43±104.89)ng/mL]and the control group [(2.16±0.51)ng/mL, (114.66±74.31)ng/mL] (P<0.05). There was no statistically significant difference in the positive detection rate of serum β₂-MG or SF between the HTN group, CHD group and CHD and HTN group(P>0.05).Conclusions The levels of CEA and AFP remain unchanged in patients with HTN, CHD and CHD and HTN. β₂-MG and SF participate in the physiological and pathological processes of HTN, CHD and CHD and HTN so that β₂-MG and SF can be used as indexes for clinical diagnosis of prognosis and efficacy.

Key words： alpha fetoprotein carcinoembryonic antigen serum ferritin β₂-microglobulin coronary heart disease hypertension

Received: 22 January 2021

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	ZHANG Lin
	LI Haoting
	WANG Na
	LV Jungang
	ZHAI Li

Cite this article:

ZHANG Lin,LI Haoting,WANG Na等. Changes and clinical significance of serum AFP, CEA, SF, β₂-MG in patients with coronary heart disease and hypertension[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(2): 154-157.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I2/154

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