抗凝治疗方法对抗磷脂综合征患者助孕及妊娠结局的影响

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Abstract Objective To explore the effect of different anticoagulant therapies on pregnancy assistance and pregnancy outcomes in patients with antiphospholipid syndrome (APS). Methods Three hundred and twelve patients with antiphospholipid syndrome filed in the Department of Obstetrics of our hospital between January 2015 and December 2020 were selected as the subjects. A retrospective cohort study was conducted.These patients were divided into the aspirin group (group A, 98 cases), aspirin combined with low molecular weight heparin group after pregnancy (group B, 101 cases) and aspirin combined with low molecular weight heparin group after ovulation (group C, 113 cases). Observation lasted until 6 weeks postpartum. The differences in pregnancy assistance and pregnancy outcomes between the three groups were studied. Results The abortion rate (2.65%) and biochemical pregnancy rate (5.31%) in group C were significantly lower than in group B (9.90%, 14.85%) and group A (15.31%, 26.53%), but the live birth rate (90.27%) was significantly higher than in group B (68.32%) and group A (51.02%) (all P<0.05). The incidence of preeclampsia (3.92%), fetal growth restriction (1.96%), placental abruption (0.98%) and preterm birth (2.94%) in group C was significantly lower than in group B (13.04%, 8.69%, 7.25%, 10.14%) and group A (20.00%, 22.00%, 8.00%, 14.00%) (P<0.05). The incidence of fetal distress (1.96%) and premature rupture of membranes (3.92%) in group C was significantly lower than in group B (8.69%, 13.04%) and group A (14.00%, 20.00%) (P<0.05). Conclusions Aspirin combined with low molecular weight heparin after ovulation can improve the live birth rate of patients with antiphospholipid syndrome, reduce the abortion rate and biochemical pregnancy rate, and significantly improve pregnancy outcome.

Key words： pregnancy outcome antiphospholipid syndrome aspirin low molecular weight heparin

Received: 06 November 2021

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	WANG Jing
	DONG Xing
	BU Wenhua
	SHANG Lixin

Cite this article:

WANG Jing,DONG Xing,BU Wenhua等. Effect of different anticoagulant therapies on pregnancy assistance and pregnancy outcomes in patients with antiphospholipid syndrome[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(3): 226-230.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I3/226

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