白藜芦醇通过MyD88/TLR4/NF-kB信号通路诱导结肠癌细胞凋亡的机制

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Abstract Objective To investigate the mechanism of apoptosis of colon cancer cells induced by resveratrol through MyD88/TLR4/ NF-KB signaling pathway.Methods With different doses of resveratrol for 24 h, TUNEL assay was used to detect the apoptosis rate of colon cancer cells and Western blot and RT-PCR were employed to test the expression of key signal molecules in MyD88/TLR4/NF-kB signaling pathway.Results The apoptosis rates of HT-29, SW480 and LoVo significantly increased after treatment. The protein and mRNA levels of Bax and Cleaved Caspase 3 significantly increased and Bcl-2 was downregulated. The expression of VEGF protein in cell supernatant decreased significantly. MyD88, TLR4 and NF-KB were significantly down regulated (P<0.05).Conclusions Resveratrol may promote the apoptosis of colon cancer cells through MyD88/TLR4/ NF-KB signaling pathway to inhibit the development of tumor.

Key words： resveratrol colon cancer MyD88 TLR4 NF-kB

Received: 10 September 2021

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	Articles by authors
	QIAO Lu
	YANG Yan
	TANG Daishi
	DU Ting
	GU Yong

Cite this article:

QIAO Lu,YANG Yan,TANG Daishi等. Mechanism of apoptosis of colon cancer cells induced by resveratrol through MYD88 / TLR4 / NF-KB signaling pathway[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(4): 298-302.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I4/298

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