双源CT灌注成像在活体肝移植后对移植肝的评价作用

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Abstract Objective To explore the role of dual-source CT perfusion imaging in evaluating liver transplantation after living donor liver transplantation (LDLT).Methods Twenty-five patients without hepatic artery stenosis according to ultrasound and CTA examination one month after LDLT were enrolled between June 2013 and November 2018. Another 61 patients were selected three months after surgery, including 25 patients without hepatic artery stenosis, 13 with mild stenosis, 12 with moderate stenosis, and 11 with severe stenosis. Another 25 patients who received CT perfusion scanning in the same period because they were suspected of liver tumor but confirmed otherwise by clinical examination and imaging were collected as the control group. All these subjects underwent the examination of dual-source CT perfusion imaging of the whole liver. Hepatic artery perfusion (HAP), portal vein perfusion (PVP), total liver perfusion (TLP), and hepatic perfusion index (HPI) were measured. Simultaneously, the level of alanine transaminase (ALT) of patients with hepatic artery stenosis was detected.Results HAP of patients without hepatic artery stenosis one month after liver transplantation [(0.36±0.17)ml/(min·ml] was significantly higher than in the control group (0.28±0.13) (P<0.05). HAP of patients with moderate and severe hepatic artery stenosis was significantly lower [(0.12±0.09)ml/(min·ml), (0.06±0.03)ml/(min·ml), P<0.05]. HPI of patients with moderate and severe hepatic artery stenosis was significantly lower than that of patients in the control group (0.07±0.05, 0.03±0.02 vs. 0.23±0.16, P<0.05). PVP of patients with severe hepatic artery stenosis was significantly higher than that of patients in the control group [(1.81±0.36)ml/(min·ml vs. (1.23±0.62)ml/(min·ml), P<0.05]. In patients with hepatic artery stenosis, the logarithm of ALT was linearly correlated with that of HAP.Conclusions Dual-source CT can be used to evaluate the blood perfusion of the transplanted liver of patients after LDLT, provide more accurate information for clinical application, and improve the accuracy of subsequent treatment of patients.

Key words： CT perfusion imaging living donor liver transplantation haemodynamics hepatic artery stenosis

Received: 25 September 2021

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	Articles by authors
	LIU Jiaxiong
	CHEN Xiaoxia
	HE Xucheng
	YAO Dingming
	HAN Wenjuan
	LIU Muqing
	HUA Rongrong
	WANG Guisheng

Cite this article:

LIU Jiaxiong,CHEN Xiaoxia,HE Xucheng等. The role of DSCT perfusion imaging in evaluating transplanted livers after living donor liver transplantation[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(4): 323-326.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I4/323

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