高强度聚焦超声消融术联合不同药物治疗子宫腺肌病的临床疗效

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Abstract Objective To compare the clinical effect of only high intensity focused ultrasound ablation surgery (FUAS), FUAS combined with levonorgestrel releasing intrauterine system (LNG-IUS) and FUAS combined with dienogest(DNG) in the treatment of adenomyosis(AM). Methods A total of 150 patients with AM, who were treated in our hospital, were divided into three groups according to the difference of drug use: group A (FUAS treatment only), group B (FUAS combined with LNG-IUS) and group C (FUAS combined with DNG), with 50 cases in each group. The uterine volume, lesion volume, dysmenorrhea score, hemoglobin (HB) and level of serum CA125 were recorded separately at four points, namely before ablation (T₁), 3 th(T₂) ,6 th(T₃) and 12 th(T₄) month after ablation. Results Compared with the point of T₁, at the points of T₂-T₄, the uterine volume, lesion volume, serum CA125 and VAS scores decreased (P<0.01) and HB became significantly higher (P<0.01) in the three groups. At the point of T₄, the above mentioned four data were lower (P<0.05 ) in group B and group C than those in group A, and the uterine volume, dysmenorrhea score and serum CA125 in group C were significantly lowerthan those in group B (P<0.01). Conclusions The three treatment methods of FUAS are effective to prevent the recurrence and improve the clinical symptoms effectively, especially the treatment of FUAS combined with DNG.

Key words： adenomyosis high intensity focused ultrasound ablation surgery levonorgestrel releasing intrauterine system dienogest CA125

Received: 20 February 2022

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	Articles by authors
	DONG Xin
	ZHANG Yaqin
	PANG Xiaoqing
	QIN Lixin
	YANG Mo
	REN Peng
	LI Xiaoxue

Cite this article:

DONG Xin,ZHANG Yaqin,PANG Xiaoqing等. Clinical effect of high intensity focused ultrasound ablation surgery combined with different drugs in treatment of adenomyosis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(10): 843-847.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I10/843

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