新生儿B组溶血性链球菌败血症或合并脑膜炎9例临床分析

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (929 KB) HTML (0 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To analyze the diagnosis, treatment and prognosis of neonatal GBS sepsis or meningitis. Methods The clinical data and maternal status of 9 neonates with GBS septicemia admitted into the neonatal ward of our hospital from 2017 to 2020 were retrospectively analyzed. Results Among the 9 children with GBS septicemia, only 1 was GBS positive screened before delivery and given penicillin prophylactic treatment, 6 were GBS negative screened during pregnancy, and 2 were not screened for GBS (1 of them was premature). There were 7 cases of early onset sepsis, 2 cases of late onset sepsis, all accompanied by CRP elevation, 5 cases of meningitis, 3 cases of pneumonia, 6 cases of fever, 3 cases of convulsion, and 1 case of death. The rest were followed up to 6-24 months, 1 case of developmental lag, and the rest were normal. Nine strains of GBS detected by blood culture were sensitive to penicillin, ampicillin, linezolid, vancomycin and furantin, and resistant to clindamycin. One strain was resistant to ceftriaxone, and one strain was sensitive to tetracycline. Conclusions There is still a possibility of missed diagnosis in prenatal GBS screening. Neonatal GBS sepsis progresses rapidly with a high rate of death and disability, requiring early identification, timely detection and targeted anti-infection treatment, most of which require combined drugs.

Key words： group B streptococcus sepsis meningitis pneumonia

Received: 24 June 2022

ZTFLH:

R722.13+1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I11/927

[1]	Jennifer R V, Nancy L S, Ruth L, et al. Early-onset group B streptococcal disease in the United States: potential for further reduction [J]. Obstet Gynecol, 2014, 123 (4) : 828-837.
[2]	邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].5版.北京:人民卫生出版社,2019:513-518.
[3]	中华医学会儿科学分会新生儿学组,中国医师协会新生儿科.医师分会感染专业委员会.新生儿败血症诊断及治疗专家共识(2019年版)[J].中华儿科杂志,2019,57(4):252-257.
[4]	王月丽.妊娠晚期孕妇生殖道B族链球菌感染对产妇分娩结局和新生儿预后的影响[J] .抗感染药学,2018,15(7).1164-1166.
[5]	曹雪莲.生殖道B族链球菌感染对妊娠晚期孕妇妊娠结局及新生儿的影响[J].中国医学创新,2019,16(10):141-144.
[6]	王茜,马良坤,宋英娜,等.妊娠晚期 B 族链球菌感染的筛查方法及妊娠结局分析[J].中华医学杂志,2016,96(15):1188-1191.
[7]	杨永弘,朱荫芝. B族链球菌感染的研究进展[J].北京医学,1997,19(3): 169-171.
[8]	Hughes R G, Brocklehurst P, Steer P J, et al. Stenson BM on behalf of the royal college of obstertricians and gyanecologists. prevention of early-onset neonatal group B streptococcal disease[S].Green-top Guideline, 2017, 124:280-305.
[9]	中国妇幼保健协会新生儿保健专业委员会.中国医师协会新生儿科医师分会.母婴同室早发感染高危新生儿临床管理专家共识(2021版)[J].中华围产医学杂志,2021,24(8):567-575.
[10]	范小萍,叶旭芳,毛月燕,等. 新生儿GBS感染败血症患儿血乳酸和血清炎症指标水平及临床意义[J].中国妇幼保健,2020,35(24):4764-4766.
[11]	赵江红,杨晗,周坤文,等.10例孕母GBS筛查阴性新生儿GBS败血症或合并脑膜炎病例临床分析[J].中国感染控制杂志,2019,18(7):633-637.
[12]	邱斌,李钢,范小莲,等.联合检测血管内皮生长因子、腺苷脱氨酶在结核性脑膜炎和病毒性脑膜炎鉴别诊断中的价值[J].武汉大学学报(医学报),2009,30 (6): 806-809.
[13]	刘钢,张二清,陈荷英,等.儿童化脓性脑膜炎不良预后危险因素探讨[J].临床儿科杂志,2011,29(2): 148-152.
[14]	杨晓岩,张雁行,程宪.新生儿B组链球菌感染所致化脓性脑膜炎的治疗分析[J].中国医药指南,2019,17(2):35-36.

[1]	. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(5): 459-460.