中国人群先天性白内障危险因素的Meta分析

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Abstract Objective To explore the risk factors of congenital cataracts in Chinese population.Methods CNKI, VIP, WanFang Data, Pubmed and Embase databases were searched from inception to November 30th, 2021. Meta-analysis was conducted with RevMan5.4 software.Results Six articles were included, with a total of 650 cases and 1353 controls. The meta-analysis results showed that the risk factors for congenital cataract in the Chinese population were as follows, oxygen therapy after birth (OR=5.50, 95%CI: 1.66-18.20), family genetic history (OR=6.97, 95%CI: 2.76-17.62), infections during pregnancy (OR=2.06, 95%CI: 1.38-3.06), poor nutritional status during pregnancy (OR=2.55, 95%CI: 1.17-5.56), medications during pregnancy (OR=4.49, 95%CI: 1.74-11.59), suffering from ischemic hypoxic encephalopathy (OR=6.42, 95%CI: 1.35-30.53), premature delivery (OR=2.14, 95%CI: 1.28-3.60), low birth weight (OR=4.04, 95%CI: 2.11-7.75), peripheral blood serum complement C₃ level decreased (OR=1.04, 95%CI: 1.02-1.07), CRYAA and CRYAB gene single nucleotide polymorphism: CRYAArs7278468 GT+TT allele (OR=6.03, 95%CI: 1.27-28.53), CRYABrs370803064 AA+GA allele (OR=5.81, 95%CI: 1.57-21.56), CRYABrs387907338 TT+TC allele (OR=2.47, 95%CI: 1.34-4.58), and CRYAB gene TA haplotype (OR=1.80, 95%CI: 1.10-2.95).Conclusions Congenital cataract is influenced by many factors, among which drug use during pregnancy, low birth weight, hypoxic ischemic encephalopathy and postnatal oxygen therapy are the most influential factors.

Key words： Chinese congenital cataract incidence risk factors Meta-analysis

Received: 16 July 2022

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	SHI Lijuan
	LI li
	SHI Fuyan
	LI Manmei
	WANG Xue
	WU Zhihong

Cite this article:

SHI Lijuan,LI li,SHI Fuyan等. Meta analysis of risk factors for congenital cataract in Chinese population[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(12): 1033-1037.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I12/1033

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