不同筛查方法对宫颈高级别鳞状上皮内病变及以上的检出情况

Abstract
Figure/Table
References
Related Citation (1)

Download: PDF (966 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the detection of high-grade squamous intraepithelial lesion or worse by thinprep cytologic test (TCT), high-risk human papillomavirus (HPV) detection and combined screening methods. Methods A total of 1721 women referred for colposcopy at gynecology clinic of Beijing Obstetrics and Gynecology Hospital from June to November of 2019 were included, and the results of TCT screening, HPV detection and cervical biopsy pathology were retrospectively analyzed. Results In the 1721 cases,the average age was 41.04±10.84 ranged from 19 to 78 years old. The detection rates of high-grade squamous intraepithelial lesions (HSIL) or worse by biopsy in AUSCUS, LSIL, ASC-H, HSIL and AGC groups were 22.6%, 25.0%, 77.3%, 90.9% and 60.0% respectively, which were significantly higher than that in NILM group (14.2%, P＜0.05). The detection rates of HSIL or worse by biopsy in HPV 16/18 positive and other HR-HPV positive groups were 22.8% and 19.0%, which were significantly higher than that in the HPV negative group (7.3%,P＜0.05). The detection rate of HSIL or worse in the positive group by TCT and HPV detection was 31.3% (205 /656), which was significantly higher than that in the control group(13.7%,146/1065; P<0.001). Conclusions TCT and high-risk HPV detection are important methods of screening HSILor worse. The patients with TCT ASC-US or worse combined with high-risk HPV should be paid more attention to improve the detection rate.

Key words： thinprep cytologic test high-risk HPV TCT combined with high-risk HPV detection high-grade squamous intraepithelial lesions

Received: 20 May 2022

ZTFLH:

R713

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LU Chang
	CHEN Xinyi
	WANG Xiaodan
	LIU Zhaohui

Cite this article:

LU Chang,CHEN Xinyi,WANG Xiaodan等. Detection of high-grade squamous intraepithelial lesions or worse by different screening methods[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(3): 194-197.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I3/194

[1]	Siegel R L, Miller K D, Fuchs H E, et al. Cancer statistics, 2021[J]. CA Cancer J Clin, 2021, 71(1):7-33.
[2]	李婷婷,王翠峰.高危型人乳头瘤病毒联合宫颈液基薄层细胞学检测在宫颈上皮内瘤变筛查中的应用价值[J]. 中国全科医学, 2021. 24(9): 1106-1110.
[3]	赵昀, 魏丽惠. CSCCP关于中国宫颈癌筛查及异常管理相关问题专家共识解读[J]. 实用妇产科杂志, 2018. 34(2): 101-104.
[4]	Hu L, Bell D, Antani S, et al. An Observational study of deep learning and automated evaluation of cervical images for cancer screening[J]. J Natl Cancer Inst, 2019,111(9):923-932.
[5]	赵超,赵昀,崔淑慧, 等.高危型HPV及联合检测在子宫颈癌机会性筛查中的价值[J].中国妇产科临床杂志,2016,17(2):119-121.
[6]	Wentzensen N, Clarke M A, Bremer R, et al. Clinical evaluation of human papillomavirus screening with p16/Ki-67 dual stain triage in a large organized cervical cancer screening program[J]. JAMA Intern Med, 2019,179(7):881-888.
[7]	Lew J B, Simms K T, Smith M A, et al. Primary HPV testing versus cytology-based cervical screening in women in Australia vaccinated for HPV and unvaccinated: effectiveness and economic assessment for the National Cervical Screening Program[J]. Lancet Public Health, 2017, 2(2): e96-e107.
[8]	Wang W, Arca E, Sinha A, et al. Cervical cancer screening guidelines and screening practices in 11 countries: a systematic literature review[J]. Prev Med Rep. 2022, 8(28):101813.
[9]	Chrysostomou A C, Stylianou D C, Constantinidou A, et al. Cervical cancer screening programs in Europe: the transition towards HPV vaccination and population-based HPV testing[J]. Viruses, 2018, 10(12):729.
[10]	沈洁,高丽丽,张月,等.北京市宫颈癌筛查妇女中高危型HPV感染状况及在宫颈癌前病变中的分布[J].中华预防医学杂志,2018,52(5):493-497.
[11]	靳梦杰,胡倩,李强,等.人染色体端粒酶基因、TCT结合HPV检测用于宫颈组织病变的诊断价值[J].武警医学,2021,32(12):1025-1029.
[12]	Perkins R B, Guido R S, Castle P E, et al. 2019 ASCCP Risk-Based Management Consensus Guidelines for abnormal cervical cancer screening tests and cancer precursors[J]. J Low Genit Tract Dis, 2020, 24(2):102-131.
[13]	吕涛,吴忧,廖秦平, 等.高危型人乳头瘤病毒E6/E7 mRNA在宫颈细胞学ASCUS/LSIL/ASC-H分流中的意义[J].现代妇产科进展,2017,26(9):670-673.
[14]	陆夏良,展瑞,赵光明,等.人乳头状瘤病毒感染患者宫颈病理分析[J].中国临床医生杂志,2021,49(11):1364-1366.
[15]	US Preventive Services Task Force, Curry S J, Krist A H, et al. Screening for cervical cancer: US preventive services task force recommendation statement[J]. JAMA, 2018, 320(7): 674-686.
[16]	赵健,郭雯雯,冯慧. 21～24岁年轻女性子宫颈癌筛查建议及子宫颈病变的处理[J].中国实用妇科与产科杂志,2020,36(7):608-616.