强直性脊柱炎全脊柱后凸角对心肺功能的影响

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Abstract Objective To analyze the characteristics of cardiopulmonary function in patients with ankylosing spondylitis (AS), and explore the influence of global kyphosis (GK) on cardiopulmonary function.Methods Retrospective analysis of the clinical data of 46 patients with AS complicated with kyphosis admitted to Beijing Dawang Lu Emergency Hospital from October 2021 to October 2022. According to the to global kyphosis Angle, they were divided into severe group (GK > 95°), 23 cases in the moderate group (80°≤ GK ≤ 95°). Statistical correlations of Pearson or Spearman were used to analyze the effect of GK angle on lung function indexes, and basic cardiac structure and functional parameters in both groups.Results As the GK angle increases, the diameter of the atrioventricular cavity (left atrial diameter, left ventricular diameter in end diastole, leftventriculardiameterinendsystole, right atrial diameter, right ventricular diameter), the ratio of early diastolic peak velocity to late diastolic peak velocity (E/A), and the ratio of early diastolic velocity to late diastolic velocity (e’/a’) of the mitral septal ring gradually decrease, while E/e’gradually increases, There was a significant statistical difference between groups (P<0.05).The pulmonary function results of the included patients showed: Compared with the moderate group, the severe group had varying degrees of decreased restrictive ventilation function, small airway function and gas exchange function parameters (P<0.05). Correlation analysis showed that, as the GK Angle increases, the left atrioventricular cavity size (LAD, LVDD, LVSD) and diastolic function parameters (E/A, e’/a’) gradually decreased, showing a significant negative correlation (P<0.05); There was a significant negative correlation between GK angle and parameters of pulmonary restrictive ventilation function (P<0.05).Conclusions GK angle of AS patients has certain influence on cardiopulmonary function. The larger the GK angle is, the smaller the atrioventricular cavity diameter is, and the worse the left ventricular diastolic function is. At the same time, the results showed that the larger the GK angle was, the worse the corresponding pulmonary function of patients was.

Key words： ankylosing spondylitis global kyphosis pulmonary function echocardiography cardiac structure

Received: 06 January 2023

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	Articles by authors
	YANG Yunfei
	XIA Qingfu
	HUANG Lijun
	ZHAO Guofeng
	XIA Jiyuan
	TIAN Xinqi
	LIU Chang

Cite this article:

YANG Yunfei,XIA Qingfu,HUANG Lijun等. Effect of kyphosis in ankylosing spondylitis on cardiopulmonary function[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(5): 384-388.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I5/384

[1]	Mease Philip J. Suspecting and diagnosing the patient with spondyloarthritis and what to expect from therapy[J]. RDCNA,2022,48(2), 507-521.
[2]	Sieper J, Poddubnyy D. Axial spondyloarthritis[J]. Lancet, 2017, 390(10089):73-84.
[3]	Ragnarsdottir M, Geirsson A J, Gudbjornsson B. Rib cage motion in ankylosing spondylitis patients: a pilot study[J]. Spine Journal, 2008, 8(3):505-509.
[4]	Chang K W, Leng X, Zhao W, et al. Quality control of reconstructed sagittal balance for sagittal imbalance[J]. Spine (Phila Pa 1976), 2011, 36(3):E186-E197.
[5]	Suk K S, Kim K T, Lee S H, et al. Significance of chin-brow vertical angle in correction of kyphotic deformity of ankylosing spondylitis patients[J]. Spine (Phila Pa 1976), 2003, 28(17): 2001-2005.
[6]	Kim K T, Suk K S, Cho Y J, et al. Clinical outcome results of pedicle subtraction osteotomy in ankylosing spondylitis with kyphotic deformity[J]. Spine (Phila Pa 1976), 2002, 27(6):612-618.
[7]	Cho H, Kim T, Kim T H, et al. Spinal mobility, vertebral squaring, pulmonary function, pain, fatigue, and quality of life in patients with ankylosing spondylitis[J]. Ann Phys Rehabil Med, 2013, 37(5):675-682.
[8]	钱邦平,邱勇,王斌,等. 强直性脊柱炎胸腰椎后凸畸形肺功能的影响因素分析[J]. 中华外科杂志, 2009, 47(2):149-150.
[9]	Liu C, Wu B, Guo Y, et al. Correlation between diaphragmatic sagittal rotation and pulmonary dysfunction in patients with ankylosing spondylitis accompanied by kyphosis[J]. J Int Med Res, 2019, 47(5):1877-1883.
[10]	Liu J, Qi Y, Zheng L, et al. Xinfeng capsule improves pulmonary function in ankylosing spondylitis patients via NF-κB-iNOS-NO signaling pathway[J]. J Tradit Chin Med, 2014, 34(6):657-665.
[11]	Kanathur N, Lee-Chiong T. Pulmonary manifestations of ankylosing spondylitis[J]. Clin Chest Med, 2010, 31(3):547-554.
[12]	Berdal G, Halvorsen S, van der Heijde D, et al. Restrictive pulmonary function is more prevalent in patients with ankylosing spondylitis than in matched population controls and is associated with impaired spinal mobility: a comparative study[J]. Arthritis Res Ther, 2012, 14(1): R19.
[13]	Culham E G, Jimenez H A, King C E. Thoracic kyphosis, rib mobility, and lung volumes in normal women and women with osteoporosis[J]. Spine (Phila Pa 1976), 1994, 19(11): 1250-1255.
[14]	赵陆,刘超,张永刚,等. 强直性脊柱炎胸腰椎后凸畸形患者膈肌旋转与肺功能的相关性分析[J]. 中国脊柱脊髓杂志, 2015, 25(9): 811-814.
[15]	Baniaamam M, Heslinga S C, Boekel L, et al. The prevalence of cardiac diseases in a contemporary large cohort of dutch elderly ankylosing spondylitis patients-the CARDAS study[J]. J Clin Med, 2021, 10(21):5069-5081.
[16]	陈进伟. 重视强直性脊柱炎关节外表现的诊治[J]. 中华风湿病学杂志, 2012, 16(9): 577-579.
[17]	Peters M J, Visman I, Nielen M M, et al. Ankylosing spondylitis: a risk factor for myocardial infarction?[J]. Ann Rheum Dis, 2010, 69(3):579-581.
[18]	Hsieh L F, Wei J C, Lee H Y, et al. Aerobic capacity and its correlates in patients with ankylosing spondylitis[J]. Int J Rheum Dis, 2016, 19(5):490-499.
[19]	Eddarami J, Azzouzi H, Ichchou L. Heart involvement in a moroccan population with spondyloarthritis: across-sectional study[J]. J Saudi Heart Assoc, 2021, 33(2):191-197.
[20]	Fu J, Wu M, Liang Y, et al. Differences in cardiovascular manifestations between ankylosing spondylitis patients with and without kyphosis[J]. Clin Rheumatol, 2016, 35(8):2003-2008.
[21]	Fu J, Song K, Zhang Y G, et al. Changes in cardiac function after pedicle subtraction osteotomy in patients with a kyphosis due to ankylosing spondylitis[J]. Bone Joint J, 2015, 97-B(10):1405-1410.
[22]	Siao W Z, Liu C H. Increased risk of valvular heart disease in patients with ankylosing spondylitis: a nationwide population-based longitudinal cohort study[J]. Ther Adv Musculoskelet Dis, 2021, 13:1-10.
[23]	Ozkan Y. Cardiac involvement in ankylosing spondylitis[J]. J Clin Med Res, 2016, 8(6):427-430.