神经调节蛋白4对2型糖尿病大鼠心肌细胞凋亡的影响

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Abstract Objective To investigate the effects of neuregulin 4 (Nrg4) on myocardial apoptosis of type 2 diabetic rats. Methods SD rats were randomly divided into vehicle group, diabetes mellites (DM) group and Nrg4 administration group (Nrg4). The apoptosis rate of myocardial cells was detected by flow cytometry, the expression of Bax and Bcl-2 transcription were detected by qRT-PCR, and the expression of apoptosis-related proteins Bax, Bcl-2 and Cleaved caspase 3 were detected by Western blot. Results Compared with the vehicle group, DM significantly promoted cell apoptosis [(35.49±1.37)% vs. (11.98±0.85)%; P＜0.05], heightened Bax and cleaved-caspase 3 expression, and reduced Bcl-2 expression (P＜0.05). While CBD obviously inhibited cell apoptosis [(19.28±0.96)% vs. (35.49±1.37)%; P＜0.05], reduced Bax and cleaved-caspase 3 expression, and increased Bcl-2 expression (P＜0.05). Conclusions Nrg4 attenuates myocardial apoptosis of type 2 diabetic rats.

Key words： Neuregulin 4 (Nrg4) type 2 diabetes cardiomyocyte cell apoptosis

Received: 05 December 2022

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	Articles by authors
	SU Jinghua
	WU Fangli
	JIAO Ting
	HAN Ning
	SU Jingke
	ZHANG Haisong

Cite this article:

SU Jinghua,WU Fangli,JIAO Ting等. Effects of Nrg4 on myocardial apoptosis of type 2 diabetic rats[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(7): 557-561.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I7/557

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