结直肠癌根治术患者应用普瑞巴林联合腰方肌阻滞麻醉的效果

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Abstract Objective To explore the effect of pregabalin combined with in quadratus lumborum block anesthesia patients undergoing radical surgery of colorectal cancer.Methods Sixty-six patients who met the requirements after radical surgery of colorectal cancer from January to October 2022 were selected and randomly divided into a control group (n=22), a quadratus lumborum block anesthesia group (n=22) and a pregabaline group (n=22). Patients in the three groups were treated with postoperative controlled intravenous analgesia (PCIA). Patients in the pregabalin group, the quadratus lumborum block anesthesia group and the quadratus lumborum block after anesthesia induction. Patients in the pregabalin group received 150 mg pregabalin capsules before surgery, and 75 mg each at 8:00 p.m. on the first day and 30 minutes before surgery. Patients in quadiatus lumborum group and control group were given placebo at the same time. VAS score, intraoperative dosage of sufentanil and remifentanil, serum CRP and cortisol concentrations 1 day before surgery and 15 min after skin resection, 24 h and 48 h after surgery, vital signs before surgery and 15 min after skin resection, and adverse reactions 2 days after surgery, as well as the time of landing,exhausting,drinking and hospitalization after operation and the number of times to press the analgesic pump, were all compared among the three groups.Results At 2, 12, 24 and 48 h after surgery, the resting VAS score and exercise VAS score of the three groups increased and then decreased, while the resting VAS score and exercise VAS score of the control group, quadratus lumborum group and pregabalin group decreased successively at each time point, with statistical differences among the groups (P<0.05). The incidence of postoperative nausea and vomiting in the control group (40.1%), quadratus lumborum group (18.9%) and pregabalin group (9.1%) decreased successively, and there was a statistical difference between pregabalin group and control group (P<0.05). The intraoperative usage of sufentanil and remifentanil in pregabalin group was significantly lower than that in quadratus lumborum group, and the latter was lower than that in control group, with statistical significance (P<0.05). In pregabalin group, quadratus lumborum block anesthesia group; and control group, the time of first postoperative landing, exhausting, drinking and the number of pressing the analgesic pump were successively shortened or decreased (P<0.05).Conclusions Preoperative oral pregabalin combined with ultrasound in bilateral quadratus lumborum block anesthesia; for patients after laparoscopic radical surgery of colorectal cancer can achieve good analgesic effect, reduce the use of opioid drugs, reduce the incidence of postoperative nausea and vomiting, and facilitate postoperative rehabilitation of patients.

Key words： pregabalin quadratus lumborum block anesthesia radical surgery of colorectal cancer postoperative rehabilitation postoperative pain

Received: 20 January 2023

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	ZHANG Chen
	SUN Mingyue
	LIU Qinghua
	GAO Minglong

Cite this article:

ZHANG Chen,SUN Mingyue,LIU Qinghua等. Effect of pregabalin combined with quadratus lumborum block anesthesia in patients undergoing radical surgery of colorectal cancer[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(8): 672-677.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I8/672

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