基于AHNAK2构建预测肺腺癌患者生存的列线图模型

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Abstract Objective To explore the expression of AHNAK2 in lung adenocarcinoma and to construct a nomogram to predict the survival of lung adenocarcinoma patients based on AHNAK2.Methods The expression of AHNAK2 in tumor tissues and normal tissues was analyzed based on the TCGA database and the CPTAC database. The influence of AHNAK2 expression on the prognosis of patients was studied by drawing the survival curve of AHNAK2, and the variables were screened by COX multivariate analysis and included in the nomogram model to predict the prognosis and survival of patients.Results The mRNA and protein levels of AH- NAK2 in tumor tissues were significantly higher than those in normal tissues. Survival curve analysis showed that patients with high AHNAK2 expression had a shorter overall survival time and a shorter time to the first progression of the disease than those in the low expression group. The results of COX multivariate analysis showed that the high expression of AHNAK2, T stage, N stage, TNM stage, and radiotherapy were all independent risk factors affecting the survival of patients (P<0.05).The nomogram model had good stability and accuracy. The area under the ROC curve of the model predicting 1-year, 3-year, and 5-year survival probability was 0.69, 0.76, and 0.71, respectively, and the KM survival curve of the model score suggested that the high group had a shorter survival time than the low group.Conclusions The mRNA and protein expressions of AHNAK2 in lung adenocarcinoma tissues are significantly higher than those in normal tissues, and patients with high AHNAK2 expression have poor prognosis. The nomogram model based on AHNAK2 has good stability and accuracy.

Key words： AHNAK2 lung adenocarcinoma nomogram

Received: 19 September 2022

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	FAN Jing
	ZHAO Haibin

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FAN Jing,ZHAO Haibin. Construction of a nomogram model for predicting survival of patients with lung adenocarcinoma based on AHNAK2[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(8): 682-687.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I8/682

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