非透析慢性肾脏病患者肌钙蛋白T校正公式的建立

Abstract
Figure/Table
References
Related Citation (10)

Download: PDF (1022 KB) HTML (0 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigatethe relationshipbetween troponin T (cTnT) and common clinical indicators in patients with chronic kidney disease (CKD), and to establish a correction formula for cTnT in non-dialysis CKD patients. Methods TheClinical indicators of 690 non-dialysis hospitalized CKD patients were retrospectively analyzed,including age, sex, basal metabolic rate (BMI), estimated glomerular filtration rate (eGFR), serum creatinine (CR), serum uric acid (UA), blood urea nitrogen (BUN), albumin (ALB), cholesterol (CHOL), triglyceride (TG), hemoglobin (HGB), hematocrit (HCT), red blood cell distribution width (RDW), red blood cell count (RBC), CKD stage. The logarithm of cTnT value was taken as ln(cTnT), the dependence between ln (cTnT) and the above indexes was discussed, and the correction formula of cTnT was established. Results The abnormal rate of cTnT increased gradually with the increase of CKD stage. The cTnT levels of each stage of CKD were significantly different (P<0.05). ln(cTnT) was linearly correlated with CR, UA, BUN, HGB, ALB, HCT, RDW, RBC, CKD stage, age and eGFR (P<0.05). With CR, HGB, HCT, RBC, CKD stage there was strong correlation(| R | >0.5). Stepwise multiple linear regression analysis was adopted, and the final correction formula was cTnTcalibration=0.0124×1.3366CKD×0.9931HGB. Conclusions In the clinical investigation of acute coronary syndrome(ACS) in non-dialysis CKD patients, cTnT detection value can be compared with cTnT calibration before judgment.

Key words： chronic kidney disease troponin T correction formula stepwise multiple linear regression

Received: 27 March 2023

ZTFLH:

R692

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	KUANG Haibo
	NIE Shanhua
	YANG Cheng
	CHEN fen
	PAN Dezhang

Cite this article:

KUANG Haibo,NIE Shanhua,YANG Cheng等. Establishment of troponin T correction formula for non-dialysis patients with chronic renal disease[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(11): 977-980.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I11/977

[1]	Chaulin AM. Some common causes of false positive increases in serum levels of cardiac troponins[J].Curr Cardiol Rev, 2022, 18(6):e130422203527.
[2]	Ballew S H, Matsushita K. Cardiovascular risk prediction in CKD[J].Semin Nephrol,2018,38(3):208-216.
[3]	Hartikainen T, Westermann D. Advances in rapid diagnostic tests for myocardial infarction patients[J].Expert Rev Mol Diagn, 2023, 23(5):391-403.
[4]	Kozinski M, Krintus M, Kubica J, et al. High-sensitivity cardiac troponin assays: from improved analytical performance to enhanced risk stratification[J].Crit Rev Clin Lab Sci, 2017, 54(3):143-172.
[5]	Lingel J M, Srivastava M C, Gupta A. Management of coronary artery disease and acute coronary syndrome in the chronic kidney disease population-a review of the current literature[J].Hemodial Int,2017,21(4):472-482.
[6]	Pang L, Wang Z, Zhao Z L, et al. Associations between estimated glomerular filtration rate and cardiac biomarkers[J]. J Clin Lab Anal, 2020,34(8): e23336.
[7]	Levey A S, De Jong P E, Coresh J, et al. The definition, classification, and prognosis of chronic kidney disease: a KDIGO controversies conference report[J]. Kidney Int,2011, 80(1): 17-28.
[8]	Chesnaye N C, Al-Sodany E, Szummer K, et al. Association of longitudinal high-sensitivity troponin T with mortality in patients with chronic kidney disease[J]. J Am Coll Cardiol,2022, 79(4): 327-336.
[9]	Berger M, Baaten C, Noels H, et al. Heart and diabetes : Platelet function and antiplatelet therapy in chronic kidney disease[J]. Herz, 2022, 47(5): 426-433.
[10]	Tavares LTR, Saavedra-Silva M, López-Marcos J F, et al. Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic review[J].Diseases, 2022,10(1):12.
[11]	Petersen M, Strandkjær N, Kristensen J H, et al. Non-cardiac causes of troponin elevation[J].Ugeskr Laeger, 2023,185(20): V12220753.
[12]	Long B, Belcher C N, Koyfman A, et al. Interpreting troponin in renal disease: a narrative review for emergency clinicians[J].Am J Emerg Med, 2020,38(5):990-997.
[13]	Flores-Solís L M, Hernández-Domínguez J L. Cardiac troponin I in patients with chronic kidney disease stage 3 to 5 in conditions other than acute coronary syndrome[J].Clin Lab, 2014,60(2):281-290.
[14]	Aimo A, Georgiopoulos G, Panichella G, et al. High-sensitivity troponins for outcome prediction in the general population: a systematic review and meta-analysis[J].Eur J Intern Med, 2022,98:61-68.
[15]	Eggers K M, Hammarsten O, Lindahl B. Differences between high-sensitivity cardiac troponin T and I in stable populations: underlying causes and clinical implications[J].Clin Chem Lab Med, 2022,61(3):380-387.
[16]	Cardinaels E P, Daamen M A, Bekers O, et al. Clinical interpretation of elevated concentrations of cardiac troponin T, but not troponin I, in nursing home residents[J]. J Am Med Dir Assoc,2015, 16(10): 884-891.
[17]	Chesnaye N C, Szummer K, Bárány P, et al. Association between renal function and troponin T over time in stable chronic kidney disease patients[J]. J Am Heart Assoc, 2019, 8(21): e013091.
[18]	Nasr F M, Metwaly A, Khalik A A, et al. Value of troponin T as a screening test of cardiac structure and function in chronic kidney disease[J]. Glob Cardiol Sci Pract,2021(4): e202126.
[19]	Chaulin A M. false-positive causes in serum cardiac troponin levels[J].J Clin Med Res,2022,14(2):80-87.
[20]	Ajie O I, Azinge E C, Bello B T, et al. Clinical significance of elevated levels of cardiac troponin t in patients with chronic kidney disease at lagos university teaching hospital, lagos[J]. West Afr J Med, 2022, 39(1): 3-10.
[21]	潘德璋, 袁巧萌, 杨静,等. 慢性肾脏病1～5期心肌肌钙蛋白T参考范围的确立[J]. 华南国防医学杂志,2021,35(9): 642-646.
[22]	Kampmann J, Heaf J, Backer M C, et al. Troponin cut-offs for acute myocardial infarction in patients with impaired renal function-a systematic review and meta-analysis[J]. Diagnostics (Basel), 2022, 12(2):120.
[23]	潘德璋, 龙志军, 聂善化,等. 肌钙蛋白T水平与肾性贫血的相关性分析[J]. 武警医学,2022, 33(5): 404-407.
[24]	Haller P M, Neumann J T, Sörensen N A, et al. The association of anaemia and high-sensitivity cardiac troponin and its effect on diagnosing myocardial infarction[J]. Eur Heart J Acute Cardiovasc Care,2021,10(10): 1187-1196.
[25]	Evans M, Lewis R D, Morgan A R, et al. A Narrative review of chronic kidney disease in clinical practice: current challenges and future perspectives[J]. Adv Ther, 2022,39(1): 33-43.
[26]	Wang C K, Yen C C, Chen S Y, et al. Prognostic value of cardiac troponin in dialysis patients with paroxysmal supraventricular tachycardia[J]. Medicine (Baltimore), 2022,101(36): e30513.