2型糖尿病患者血清维生素水平及其影响因素

Abstract
Figure/Table
References (16)
Related Citation (15)

Download: PDF (997 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract

Objective To analyze the levels of serum vitamins and its influencing factors in patients with type 2 diabetes mellitus (T2DM). Methods A total of 252 T2DM patients (diabetes group) and 228 non-diabetic individuals (control group) were selected from the Aerospace Center Hospital from July 2020 to June 2022. The levels of vitamins A, B₁, B₆, B₉, B₁₂, C, D, and E were compared between the two groups. The comparison of means between the two groups was conducted using an independent samples t-test, and multiple linear regression equations were used to analyze the factors affecting the vitamins in the diabetes group, including gender, age, body mass index (BMI), glycated hemoglobin (HbA1c), and complications. Results There was no statistical difference between the diabetes group and the control group in gender and age composition. BMI, fasting blood glucose and HbA1c in the diabetes group were higher than those in the control group, and the levels of vitamin B₁, B₆, B₉, B₁₂, and C were lower than those in the control group, with statistical significance (P<0.05). The main factors affecting vitamin A in diabetic patients were gender (β=-0.1, 95% CI: -0.2, 0.0; P=0.03). The main factors affecting vitamin B9 were age 50-70 years (β=-0.9, 95% CI:-4.5, -0.6; P=0.03) and BMI > 28 (β=-2.3, 95% CI:-4.3,-0.4; P=0.02). The main factors affecting vitamin B₁₂ were gender (β=37.7, 95% CI: 0.1, 75.6; P=0.05). The main factors affecting vitamin C were gender (β=-2.4, 95% CI:-4.5, -0.4; P=0.02), BMI >28 (β=4.4, 95% CI: 1.3, 7.5; P=0.01), HbA1c>10% (β=-3.3, 95% CI:-6.2, -0.4; P=0.02), DR (β=0.9, 95% CI: 0.2, 3.1; P=0.02), DKD (β=1.5, 95% CI: 1.1, 3.6; P=0.03), and DPN (β=1.2, 95% CI: 1.0, 3.4; P=0.05). The main factors affecting vitamin D were age 50-70 years (β=-6.4, 95% CI:-12.9, 0.1; P=0.05), HbA1c 7.0-10.0% (β=7.4, 95% CI: 1.7, 13.1; P=0.01), and HbA1c>10% (β=0.3, 95% CI: 0.1, 4.9; P=0.02). Conclusions Multi-vitamin metabolism disorder exists in patients with T2DM, vitamin level is related to various clinical factors, and individualized vitamin supplementation programs should be developed according to different clinical features.

Key words： type 2 diabetes vitamin glycosylated hemoglobin complication

Received: 10 August 2023

ZTFLH:

R587.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Hong
	SHEN Yi
	DU Yangfan
	SONG Chuan
	ZHANG Xiyang
	DONG Song

Cite this article:

WANG Hong,SHEN Yi,DU Yangfan等. Analysis of serum vitamin levels and its influencing factors in patients with type 2 diabetes mellitus[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(1): 34-37.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2024/V35/I1/34

[1]	谢叶红, 黄明春. 二甲双胍降低T2DM血清维生素B12的研究进展[J].国际内分泌代谢杂志,2020,40(1):35-38.
[2]	Lind M V, Lauritzen L, Kristensen M, et al. Effect of folate supplementation on insulin sensitivity and type 2 diabetes: a meta-analysis of randomized controlled trials[J]. AJCN, 2019, 109(1): 29-42.
[3]	Hani R, Mellati A, Tabaei B S, et al. Association of serum zinc and vitamin A levels with severity of retinopathy in type 2 diabetic patients: a cross-sectional study[J]. BTER, 2019, 192(2): 123-128.
[4]	高芸,吴萍,周宇洁. 2型糖尿病不同血管并发症与脂溶性维生素及营养代谢指标的关系[J].同济大学学报, 2019, 40(5): 629-643.
[5]	Patterson S, Flatt P R, Brennan L, et al. Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion[J]. JE, 2006, 189(2): 301-310.
[6]	鲜彤章,潘琦,张丽娜,等. 住院2型糖尿病患者血清25-羟维生素D水平与糖代谢指标的相关性[J].中华临床营养杂志,2016,24(3): 144-148.
[7]	Renke G, Starling-Soares B, Basso T, et al. Effects of vitamin D on cardiovascular risk and oxidative stress[J]. Nutrients, 2023, 15(3): 769.
[8]	何玉玲,梁瑜祯.内分泌疾病与钙代谢异常[J].临床内科杂志,2013,30(3):152-153.
[9]	Yuan J, Jia P, Hua L, et al. Vitamin D deficiency is associated with risk of developing peripheral arterial disease in type 2 diabetic patients [J]. BMC Cardiovase Disord, 2019, 19:1-7.
[10]	Niu Y, Li J, Peng R, et al. Low vitamin D is associated with diabetes peripheral neuropathy in older but not in young and middle-aged patients [J]. Diabetes Metab Res Rev, 2019, 35: 1-8.
[11]	周婉,叶山东.维生素D与糖尿病慢性并发症的研究进展[J]. 中国糖尿病杂志, 2021, 29(1):67-69.
[12]	季鹏程,张舒,孙璟,等. 上海地区部分中老年糖尿病患者体内维生素水平分析[J].诊断学理论与实践,2018,17(3):285-289.
[13]	Kim Y, Oh Y K, Lee J, et al. Could nutrient supplements provide additional glycemic control in diabetes management? A systematic review and meta-analysis of randomized controlled trials of as an add-on nutritional supplementation therapy [J]. APR, 2022, 45(3): 185-204.
[14]	Nosratabadi S, Ashtray-larky D, Hosseini F, et al. The effects of vitamin C supplementation on glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis [J]. DMS 2023, 17(8): 102824.
[15]	Pramanik S, Banerjee K, Mondal L K. The amelioration of detrimental biochemical anomalies by supplementing B, C, and E vitamins in subjects with type 2 diabetes mellitus may reduce the rate of development of diabetic retinopathy [J]. JDR, 2022, 2022: 3886710.
[16]	Feng M, Shing H, Liu H, et al. High glucose-induced apoptosis in hunan endothelial cells is mediated by sequential activations of c-Jun NH2-Terminal kinase and caspase-3[J]. Circulation, 2000, 101(6): 2618.