CT定量分析在抗合成酶综合征合并间质性肺炎中的应用价值

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Abstract Objective To explore the application value of CT quantitative analysis in antisynthetase syndrome complicated with interstitial pneumonia(ASS-ILD).Methods The clinical data of 42 patients with ASS-ILD admitted to the respiratory department of Characteristics Medical Center of Chinese People's Armed Police Force from January 2015 to June 2022 were retrospectively analyzed. Quantitative software was used to automatically analyze CT images to the total lung volume (TLV) and mean lung attenuation (MLA), caculate the volume and weight of different regions and their percentage in the total lung volume, and then analyze the correlation between CT quantitative indexes and PFT parameters. CT quantitative indexes of nonspecific interstitial pneumonia with organizing pneumonia (NSIP/OP) and organizing pneumonia (OP) were compared and analyzed.Results FVC% and FEV1% were positively correlated with -500 HU to -100HU area (r＝0.58, P＝0.048; r＝0.79, P＝0.01), FEV₁/FVC was negatively correlated with -950 HU to -500 area (r＝-0.23, P＝0.01), with statistical significance (P<0.05). The bad ventilation volume (V_fibrosis%) in the NSIP/OP group was significantly higher than that in the OP group (P＝0.03), and the carbon monoxide diffusion capacity (DLCO%) was significantly lower than that in the OP group (P＝0.01). The volume of hyperventilation (V_hyper%) and weight of hyperventilation (W_hyper%) in the OP group were higher than those in the NSIP/OP group (P<0.05). The total lung average failure value (MLA_total) in the NSIP/OP group was significantly higher than that in the OP group (P<0.01).Conclusions There is a good correlation between HRCT quantitative analysis and PFT parameters, which can be used to evaluate lung function, and has reference value for NSIP/OP and OP type determination.

Key words： antisynthetase syndrome high resolution CT quantitative analysis nonspecific interstitial pneumonia organizing pneumonia

Received: 23 October 2023

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	DING Mengjiang
	LI Xueren
	PENG Shouchun
	ZHANG Yuhua

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DING Mengjiang,LI Xueren,PENG Shouchun等. Application value of CT quantitative analysis in antisynthetase syndrome complicated with interstitial pneumonia[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(2): 130-134.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2024/V35/I2/130

[1]	Li S, Ge Y, Yang H, et al. The spectrum and clinical significance of myositis-specific autoantibodies in Chinese patients with idiopathic inflammatory myopathies[J]. Clin Rheumatol, 2019, 38(8): 2171-2179.
[5]	李海兰, 刘建滨, 刘华平,等. CT肺容积参数与肺功能、临床严重程度在结缔组织相关性肺间质病变分组中的相关性研究[J]. 临床放射学杂志, 2019(2): 244-250.
[6]	Matsuoka S, Yamashiro T, Matsushita S, et al. Quantitative CT evaluation in patients with combined pulmonary fibrosis and emphysema:correlation with pulmonary function[J]. Acad Radiol,2015,22(5):626-631.
[2]	Marco J L, Collins B F. Clinical manifestations and treatment of antisynthetase syndrome[J]. Best Pract Res Clin Rheumatol, 2020,34:101503.
[3]	Lundberg I E, Tjärnlund A, Bottai M, et al. 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups[J]. Ann Rheum Dis,2017,76(12): 1955-1964.
[7]	Umakoshi H, Iwano S, Inoue T, et al. Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall:a pilot study[J].PLoS One,2017,12(9):e0185532.
[4]	Yamakawa H, Hagiwara E, Kitamura H, et al. Predictive factors for the long-term deterioration of pulmonary function in interstitial lung disease associated with anti-aminoacyl-tRNAsynthetaseantibodies[J].Respiration,2018, 96(3):210-221.
[8]	Solomon J, Swigris J J, Brown K K. Myositis-related interstitial lung disease and antisynthetase syndrome[J]. J Bras Pneumol,2011,37(1):100-109.
[5]	李海兰, 刘建滨, 刘华平,等. CT肺容积参数与肺功能、临床严重程度在结缔组织相关性肺间质病变分组中的相关性研究[J]. 临床放射学杂志, 2019(2): 244-250.
[9]	Demedts M, Costabel U. ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias[J]. Eur Respir J, 2002,19(5):794-796.
[6]	Matsuoka S, Yamashiro T, Matsushita S, et al. Quantitative CT evaluation in patients with combined pulmonary fibrosis and emphysema:correlation with pulmonary function[J]. Acad Radiol,2015,22(5):626-631.
[10]	Travis W D, Costabel U, Hansell D M, et al. An official American Thoracic Society/European Respiratory Society statement:update of the international multidisciplinary classification of the idiopathic interstitial pneumonias[J]. Am J respir Crit Care Med,2013,188(6):733-748.
[11]	Delorme S, Keller-Reichenbecher M A, Zuna I, et al. Usual interstitial pneumonia quantitative assessment of high-resolution computed tomography findings by computer-assisted texture-based image analysis[J]. Invest Radiol, 1997,32(9): 566-574.
[7]	Umakoshi H, Iwano S, Inoue T, et al. Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall:a pilot study[J].PLoS One,2017,12(9):e0185532.
[12]	Sverzellati N, Calabr Ò E, Chetta A, et al. Visual score and quantitative CT indices in pulmonary fibrosis: relationship with physiologic impairment[J]. La Radiologia Medica, 2007,112(8): 1160-1172.
[8]	Solomon J, Swigris J J, Brown K K. Myositis-related interstitial lung disease and antisynthetase syndrome[J]. J Bras Pneumol,2011,37(1):100-109.
[13]	Yanagawa M, Tanaka Y, Kusumoto M, et al. Automated assessment of malignant degree of small peripheral adenocarcinomas using volumetric CT data: correlation with pathologic prognostic factors[J]. Lung Cancer, 2010, 70(3): 286-294.
[9]	Demedts M, Costabel U. ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias[J]. Eur Respir J, 2002,19(5):794-796.
[14]	戴书华, 刘国芳, 向东生, 等. 肺磨玻璃结节CT值测量在早期癌症诊断中的意义[J]. 中华肺部疾病杂志(电子版), 2019(6):770-771.
[10]	Travis W D, Costabel U, Hansell D M, et al. An official American Thoracic Society/European Respiratory Society statement:update of the international multidisciplinary classification of the idiopathic interstitial pneumonias[J]. Am J respir Crit Care Med,2013,188(6):733-748.
[15]	陈永华, 叶彩儿, 余鑫锋, 等. 弥漫性间质性肺疾病的CT定量分析及与肺功能和视觉评估的相关研究[J]. 温州医学院学报, 2012, 42(6): 540-544.
[11]	Delorme S, Keller-Reichenbecher M A, Zuna I, et al. Usual interstitial pneumonia quantitative assessment of high-resolution computed tomography findings by computer-assisted texture-based image analysis[J]. Invest Radiol, 1997,32(9): 566-574.
[12]	Sverzellati N, Calabr Ò E, Chetta A, et al. Visual score and quantitative CT indices in pulmonary fibrosis: relationship with physiologic impairment[J]. La Radiologia Medica, 2007,112(8): 1160-1172.
[16]	Umakoshi H, Iwano S, Inoue T, et al. Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall:a pilot study[J]. PLoS One,2017,12(9):e0185532.
[13]	Yanagawa M, Tanaka Y, Kusumoto M, et al. Automated assessment of malignant degree of small peripheral adenocarcinomas using volumetric CT data: correlation with pathologic prognostic factors[J]. Lung Cancer, 2010, 70(3): 286-294.
[17]	Antin-Ozerkis D, Hinchcliff M. (2019) Connective Tissue Disease-Associated Interstitial Lung Disease: Evaluation and Management[J]. Clin Chest Med, 2019,40(3):617-636.
[14]	戴书华, 刘国芳, 向东生, 等. 肺磨玻璃结节CT值测量在早期癌症诊断中的意义[J]. 中华肺部疾病杂志(电子版), 2019(6):770-771.
[18]	Shi J, Li S, Yang H, et al. Clinical profiles and prognosis of patients with distinct antisynthetase autoantibodies[J].J Rheumatol,2017,44(7):1051-1057.
[19]	Camiciottoli G, Orlandi I, Bartolucci M, et al. Lung CT densitometry in systemic sclerosis:correlation with lung function, exercise testing, and quality of life[J]. Chest, 2007, 131(3):672-681.
[15]	陈永华, 叶彩儿, 余鑫锋, 等. 弥漫性间质性肺疾病的CT定量分析及与肺功能和视觉评估的相关研究[J]. 温州医学院学报, 2012, 42(6): 540-544.
[20]	Ohkubo H, Kanemitsu Y, Uemura T, et al. Normal lung quantification in usual interstitial pneumonia pattern: the impact of thresh-old-based volumetric CT analysis for the staging of idiopathic pulmonary fibrosis[J]. PLoS One, 2016, 11: e152505.
[16]	Umakoshi H, Iwano S, Inoue T, et al. Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall:a pilot study[J]. PLoS One,2017,12(9):e0185532.
[21]	石涵宇, 魏路清. CT定量分析在肺纤维化中的研究进展[J]. 中华放射学杂志, 2020, 54(7): 719-722.
[17]	Antin-Ozerkis D, Hinchcliff M. (2019) Connective Tissue Disease-Associated Interstitial Lung Disease: Evaluation and Management[J]. Clin Chest Med, 2019,40(3):617-636.
[18]	Shi J, Li S, Yang H, et al. Clinical profiles and prognosis of patients with distinct antisynthetase autoantibodies[J].J Rheumatol,2017,44(7):1051-1057.
[22]	Best A C, Lynch A M, Bozic C M, et al. Quantitative CT in dexes in idiopathic pulmonary fibrosis:relationship with physiologic impairment[J]. Radiology, 2003, 228(2):407- 414.
[23]	李晗, 邬雪涵, 高蓉, 等.抗合成酶综合征并发间质性肺疾病患者临床及影像特征荟萃分析[J].中华临床免疫和变态反应杂志,2022,16(5):474-482.
[19]	Camiciottoli G, Orlandi I, Bartolucci M, et al. Lung CT densitometry in systemic sclerosis:correlation with lung function, exercise testing, and quality of life[J]. Chest, 2007, 131(3):672-681.
[20]	Ohkubo H, Kanemitsu Y, Uemura T, et al. Normal lung quantification in usual interstitial pneumonia pattern: the impact of thresh-old-based volumetric CT analysis for the staging of idiopathic pulmonary fibrosis[J]. PLoS One, 2016, 11: e152505.
[24]	Do K H, Lee J S, Colby T V, et al. Nonspecific interstitial pneumonia versus usual interstitial pneumonia:differences in the density histogram of high-resolution CT[J]. J Comput Assist Tomogr, 2005, 29(4):544-548.
[21]	石涵宇, 魏路清. CT定量分析在肺纤维化中的研究进展[J]. 中华放射学杂志, 2020, 54(7): 719-722.
[22]	Best A C, Lynch A M, Bozic C M, et al. Quantitative CT in dexes in idiopathic pulmonary fibrosis:relationship with physiologic impairment[J]. Radiology, 2003, 228(2):407- 414.
[23]	李晗, 邬雪涵, 高蓉, 等.抗合成酶综合征并发间质性肺疾病患者临床及影像特征荟萃分析[J].中华临床免疫和变态反应杂志,2022,16(5):474-482.
[24]	Do K H, Lee J S, Colby T V, et al. Nonspecific interstitial pneumonia versus usual interstitial pneumonia:differences in the density histogram of high-resolution CT[J]. J Comput Assist Tomogr, 2005, 29(4):544-548.