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| Research progress on molecular mechanism and clinical efficacy of traditional Chinese medicine in treatment of rheumatoid arthritis |
| ZHANG Jing, XU Zihan, SHANG Wei |
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Received: 02 December 2023
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| [7] |
Zheng L, Zhang Z, Sheng P, et al. The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis[J]. Ageing Res Rev, 2021, 66: 101249.
|
| [1] |
Aletaha D, Smolen J S. Diagnosis and management of rheumatoid arthritis: a review[J]. JAMA,2018, 320(13): 1360-1372.
|
| [8] |
Kim J M, Lin C, Stavre Z,et al. Osteoblast-Osteoclast communication and bone homeostasis[J]. Cells, 2020, 9(9): 2073.
|
| [2] |
Oikonomopoulou K, Diamandis E P, Hollenberg M D,et al. Proteinases and their receptors in inflammatory arthritis: an overview[J]. Nat Rev Rheumatol, 2018,14(3): 170-180.
|
| [9] |
Nygaard G,Firestein G S. Restoring synovial homeostasis inrheumatoid arthritis by targeting fibroblast-like synoviocytes[J]. Nat Rev Rheumatol, 2020, 16(6): 316-333.
|
| [3] |
Haseeb A, Haqqi T M. Immunopathogenesis of osteoarthritis[J]. Clin Immunol, 2013, 146(3): 185-196.
|
| [10] |
Asadi-Samani M, Bagheri N, Rafieian-Kopaei M, et al. Inhibition of Th1 and Th17 cells by medicinal plants and their derivatives: a systematic review[J]. Phytother Res, 2017, 31(8): 1128-1139.
|
| [4] |
Jiang Q, Yang G, Liu Q,et al. Function and role of regulatory T cells in rheumatoid arthritis[J]. Front Immunol, 2021,12: 626193
|
| [11] |
Shi C, Zhang H, Wang X, et al. Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression[J]. Pharmacol Res, 2020, 151:104513.
|
| [5] |
Wang D D, Wu X Y, Dong J Y,et al. Qing-Luo-Yin alleviated experimental arthritis in rats by disrupting immune feedback between inflammatory T cells and monocytes:key evidences fromits effects on immune cell phenotypes[J]. J Inflamm Res, 2021, 14: 7467-7486.
|
| [12] |
Bao Y, Peng J, Yang K L et al. Therapeutic effects of Chinese medicine Di-Long (Pheretima vulgaris) on rheumatoid arthritis through inhibiting NF-κB activation and regulating Th1/Th2 balance[J]. Biomed Pharmacother, 2022, 147: 112643.
|
| [6] |
Charlier E, Deroyer C, Ciregia F,et al. Chondrocyte dedifferentiation and osteoarthritis (OA)[J]. Biochem Pharmacol, 2019, 165: 49-65.
|
| [13] |
Zhao Hongyan, Xu Huihui, Zuo Zhengyun, et al. Yi Shen Juan Bi Pill ameliorates bone loss and destruction induced by arthritis through modulating the balance of cytokines released by different Subpopulations of T cells[J]. Front Pharmacol, 2018, 9: 262.
|
| [7] |
Zheng L, Zhang Z, Sheng P, et al. The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis[J]. Ageing Res Rev, 2021, 66: 101249.
|
| [14] |
Zhao H, Xu H, Zuo Z, et al.Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect[J]. Int Immunopharmacol, 2018, 54: 153-162.
|
| [8] |
Kim J M, Lin C, Stavre Z,et al. Osteoblast-Osteoclast communication and bone homeostasis[J]. Cells, 2020, 9(9): 2073.
|
| [15] |
Huang R, Wang X, Zhou Y, et al. Bone Res[J]. Bone Research, 2017, 5:17019.
|
| [9] |
Nygaard G,Firestein G S. Restoring synovial homeostasis inrheumatoid arthritis by targeting fibroblast-like synoviocytes[J]. Nat Rev Rheumatol, 2020, 16(6): 316-333.
|
| [16] |
Zhou F, Mei J, Han X, et al. Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes[J]. Acta Pharm Sin B, 2019, 9(5): 973-985.
|
| [10] |
Asadi-Samani M, Bagheri N, Rafieian-Kopaei M, et al. Inhibition of Th1 and Th17 cells by medicinal plants and their derivatives: a systematic review[J]. Phytother Res, 2017, 31(8): 1128-1139.
|
| [17] |
O’Neil L J, Kaplan M J. Neutrophils in rheumatoid arthritis: breaking immune tolerance and fueling disease[J]. Trends Mol Med, 2019, 25(3): 215-227.
|
| [11] |
Shi C, Zhang H, Wang X, et al. Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression[J]. Pharmacol Res, 2020, 151:104513.
|
| [18] |
Li X, Yuan K, Zhu Q, et al. Andrographolide ameliorates rheumatoid arthritis by regulating the apoptosis-NETosis balance of neutrophils[J]. Int J Mol Sci, 2019, 20(20): 5035.
|
| [12] |
Bao Y, Peng J, Yang K L et al. Therapeutic effects of Chinese medicine Di-Long (Pheretima vulgaris) on rheumatoid arthritis through inhibiting NF-κB activation and regulating Th1/Th2 balance[J]. Biomed Pharmacother, 2022, 147: 112643.
|
| [19] |
Hwang H S, Kim H A. Chondrocyte apoptosis in the pathogenesis of osteoarthritis[J]. Int J Mol Sci, 2015, 16(11): 26035-26054.
|
| [13] |
Zhao Hongyan, Xu Huihui, Zuo Zhengyun, et al. Yi Shen Juan Bi Pill ameliorates bone loss and destruction induced by arthritis through modulating the balance of cytokines released by different Subpopulations of T cells[J]. Front Pharmacol, 2018, 9: 262.
|
| [20] |
Zhang C, Shao Z, Hu X, et al. Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies[J]. Int Immunopharmacol, 2020, 89(Pt B):107079.
|
| [14] |
Zhao H, Xu H, Zuo Z, et al.Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect[J]. Int Immunopharmacol, 2018, 54: 153-162.
|
| [21] |
Bai J, Xie N, Hou Y Y, et al. The enhanced mitochondrial dysfunction by cantleyoside confines inflammatory response and promotes apoptosis of human HFLS-RA cell line via AMPK/Sirt 1/NF-κB pathway activation[J]. Biomed Pharmacother, 2022, 149: 112847.
|
| [15] |
Huang R, Wang X, Zhou Y, et al. Bone Res[J]. Bone Research, 2017, 5:17019.
|
| [22] |
Meng M, Yue Z, Chang L, et al. Anti-Rheumatoid arthritic effects of paris saponin VII in human rheumatoid arthritis fibroblast-like synoviocytes and adjuvant-induced arthritis in rats[J]. Front Pharmacol, 2021,12: 683698.
|
| [16] |
Zhou F, Mei J, Han X, et al. Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes[J]. Acta Pharm Sin B, 2019, 9(5): 973-985.
|
| [23] |
Bai J, Xie N, Hou Y, et al. The enhanced mitochondrial dysfunction by cantleyoside confines inflammatory response and promotes apoptosis of human HFLS-RA cell line via AMPK/Sirt 1/NF-κB pathway activation[J]. Biomed Pharmacother, 2022, 149: 112847.
|
| [17] |
O’Neil L J, Kaplan M J. Neutrophils in rheumatoid arthritis: breaking immune tolerance and fueling disease[J]. Trends Mol Med, 2019, 25(3): 215-227.
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| [24] |
Wong V K W, Qiu C, Xu S W, et al.Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats[J]. Br J Pharmacol, 2019, 176(16): 2922-2944.
|
| [18] |
Li X, Yuan K, Zhu Q, et al. Andrographolide ameliorates rheumatoid arthritis by regulating the apoptosis-NETosis balance of neutrophils[J]. Int J Mol Sci, 2019, 20(20): 5035.
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| [25] |
Wu J Y, Chen Y J, Fu X Q,et al.Chrysoeriol suppresses hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes and inhibits JAK2/STAT3 signaling[J]. BMC Complement Med Ther, 2022,22(1):73.
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| [19] |
Hwang H S, Kim H A. Chondrocyte apoptosis in the pathogenesis of osteoarthritis[J]. Int J Mol Sci, 2015, 16(11): 26035-26054.
|
| [26] |
Yi L, Lyn Y J, Peng C, et al. Sinomenine inhibits fibroblast-like synoviocyte proliferation by regulating α7nAChR expression via ERK/Egr-1 pathway[J]. Int Immunopharmacol, 2018, 56: 65-70.
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| [20] |
Zhang C, Shao Z, Hu X, et al. Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies[J]. Int Immunopharmacol, 2020, 89(Pt B):107079.
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| [27] |
Pan D, Li N, Liu Y, et al. Kaempferol inhibits the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes by blocking activation of the MAPK pathway[J]. Int Immunopharmacol, 2018, 55: 174-182.
|
| [21] |
Bai J, Xie N, Hou Y Y, et al. The enhanced mitochondrial dysfunction by cantleyoside confines inflammatory response and promotes apoptosis of human HFLS-RA cell line via AMPK/Sirt 1/NF-κB pathway activation[J]. Biomed Pharmacother, 2022, 149: 112847.
|
| [28] |
Liang J, Chang B, Huang M, et al. Oxymatrine prevents synovial inflammation and migration via blocking NF-κB activation in rheumatoid fibroblast-like synoviocytes[J]. Int Immunopharmacol, 2018, 55: 105-111.
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| [22] |
Meng M, Yue Z, Chang L, et al. Anti-Rheumatoid arthritic effects of paris saponin VII in human rheumatoid arthritis fibroblast-like synoviocytes and adjuvant-induced arthritis in rats[J]. Front Pharmacol, 2021,12: 683698.
|
| [29] |
Yang Y, Chen J, Shang X, et al. Visualizing the fate of intra-articular injected mesenchymal stem cells in vivo in the second near-infrared window for the effective treatment of supraspinatus tendon tears[J]. Adv Sci (Weinh), 2019, 6(19): 1901018.
|
| [23] |
Bai J, Xie N, Hou Y, et al. The enhanced mitochondrial dysfunction by cantleyoside confines inflammatory response and promotes apoptosis of human HFLS-RA cell line via AMPK/Sirt 1/NF-κB pathway activation[J]. Biomed Pharmacother, 2022, 149: 112847.
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| [30] |
Li L, Zhou D, Liu Q, et al. Network analysis indicating the pharmacological mechanism of Yunpi-Qufeng-Chushi-prescription in prophylactic treatment of rheumatoid arthritis[J]. BMC Complement Med Ther, 2021, 21(1):142.
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| [24] |
Wong V K W, Qiu C, Xu S W, et al.Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats[J]. Br J Pharmacol, 2019, 176(16): 2922-2944.
|
| [31] |
Daily J W, Zhang T, Cao S, et al. Efficacy and safety of guizhi-shaoyao-zhimu decoction for treating rheumatoid arthritis: a systematic review and meta-analysis of randomizedclinical trials[J]. J Altern Complement Med, 2017, 23(10): 756-770.
|
| [25] |
Wu J Y, Chen Y J, Fu X Q,et al.Chrysoeriol suppresses hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes and inhibits JAK2/STAT3 signaling[J]. BMC Complement Med Ther, 2022,22(1):73.
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| [32] |
Liu W, Zhang Y, Zhu W, et al. Sinomenine inhibits the progression of rheumatoid arthritis by regulating the secretion of inflammatory cytokines and monocyte/macrophage subsets[J]. Front Immunol, 2018, 9: 2228.
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| [26] |
Yi L, Lyn Y J, Peng C, et al. Sinomenine inhibits fibroblast-like synoviocyte proliferation by regulating α7nAChR expression via ERK/Egr-1 pathway[J]. Int Immunopharmacol, 2018, 56: 65-70.
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| [33] |
Yang M, Guo M Y, Luo Y, et al. Effect of Artemisia annua extract on treating active rheumatoid arthritis: a randomized controlled trial[J]. Chin J Integr Med, 2017, 23(7): 496-503.
|
| [27] |
Pan D, Li N, Liu Y, et al. Kaempferol inhibits the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes by blocking activation of the MAPK pathway[J]. Int Immunopharmacol, 2018, 55: 174-182.
|
| [34] |
Aryaeian N, Hadidi M, Mahmoudi M, et al. The effect of black barberry hydroalcoholic extract on immune mediators in patients with active rheumatoid arthritis: a randomized, double-blind, controlled clinical trial[J]. Phytother Res, 2021, 35(2): 1062-1068.
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| [28] |
Liang J, Chang B, Huang M, et al. Oxymatrine prevents synovial inflammation and migration via blocking NF-κB activation in rheumatoid fibroblast-like synoviocytes[J]. Int Immunopharmacol, 2018, 55: 105-111.
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| [35] |
Wang M, Liu Y, Zhao L,et al. Modulating gut microbiota in autoimmune diseases: a cutting-edge strategy from prophylaxis to therapeutics[J]. Sci Bull (Beijing), 2022, 67(8): 771-773.
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| [29] |
Yang Y, Chen J, Shang X, et al. Visualizing the fate of intra-articular injected mesenchymal stem cells in vivo in the second near-infrared window for the effective treatment of supraspinatus tendon tears[J]. Adv Sci (Weinh), 2019, 6(19): 1901018.
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| [36] |
Miyauchi E, Shimokawa C, Steimle A, et al. The impact of the gut microbiome on extra-intestinal autoimmune diseases[J]. Nat Rev Immunol, 2023, 23(1): 9-23.
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| [30] |
Li L, Zhou D, Liu Q, et al. Network analysis indicating the pharmacological mechanism of Yunpi-Qufeng-Chushi-prescription in prophylactic treatment of rheumatoid arthritis[J]. BMC Complement Med Ther, 2021, 21(1):142.
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| [37] |
Qin H, Fu Y, Zhou K, et al.Toddalia asiatica extract attenuates adjuvant-induced arthritis by modulating colon Th17/Treg balance and colony homeostasis[J]. J Ethnopharmaco, 2023, 313: 116542.
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| [31] |
Daily J W, Zhang T, Cao S, et al. Efficacy and safety of guizhi-shaoyao-zhimu decoction for treating rheumatoid arthritis: a systematic review and meta-analysis of randomizedclinical trials[J]. J Altern Complement Med, 2017, 23(10): 756-770.
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| [38] |
Xi X, Ye Q, Li X,et al. Xiong fu powder regulates the intestinal microenvironment to protect bones against destruction in collagen-induced arthritis rat models[J]. Front Cell Infect Microbiol, 2022, 12: 854940.
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| [32] |
Liu W, Zhang Y, Zhu W, et al. Sinomenine inhibits the progression of rheumatoid arthritis by regulating the secretion of inflammatory cytokines and monocyte/macrophage subsets[J]. Front Immunol, 2018, 9: 2228.
|
| [33] |
Yang M, Guo M Y, Luo Y, et al. Effect of Artemisia annua extract on treating active rheumatoid arthritis: a randomized controlled trial[J]. Chin J Integr Med, 2017, 23(7): 496-503.
|
| [34] |
Aryaeian N, Hadidi M, Mahmoudi M, et al. The effect of black barberry hydroalcoholic extract on immune mediators in patients with active rheumatoid arthritis: a randomized, double-blind, controlled clinical trial[J]. Phytother Res, 2021, 35(2): 1062-1068.
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| [35] |
Wang M, Liu Y, Zhao L,et al. Modulating gut microbiota in autoimmune diseases: a cutting-edge strategy from prophylaxis to therapeutics[J]. Sci Bull (Beijing), 2022, 67(8): 771-773.
|
| [36] |
Miyauchi E, Shimokawa C, Steimle A, et al. The impact of the gut microbiome on extra-intestinal autoimmune diseases[J]. Nat Rev Immunol, 2023, 23(1): 9-23.
|
| [37] |
Qin H, Fu Y, Zhou K, et al.Toddalia asiatica extract attenuates adjuvant-induced arthritis by modulating colon Th17/Treg balance and colony homeostasis[J]. J Ethnopharmaco, 2023, 313: 116542.
|
| [38] |
Xi X, Ye Q, Li X,et al. Xiong fu powder regulates the intestinal microenvironment to protect bones against destruction in collagen-induced arthritis rat models[J]. Front Cell Infect Microbiol, 2022, 12: 854940.
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2024, Vol. 35 
