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| Relationship between genetic polymorphism of EDN1 gene and diabetic nephropathy |
| LI Diangeng1, GUO Yujie1, JIN Meiling2, GAO Lingling3, CHEN Youli4 |
1. Department of Academic Research, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing 100015, China;
2. Department of Nephrology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China;
3. Department of Internal medicine, General Hospital of Huabei Petroleum Administration Bureau,Renqiu 062552,China;
4. Effice infirmary, Comprehensive Assurance Certer, Standing Committee of Beijing Municipal People’s Congress, Beijing 101100, China |
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Abstract Objective To investigate the effect of genetic polymorphism of EDN1 gene on the incidence of type 2 diabetic nephropathy among the Han nationality in northern China. Methods This study involved 120 Han population, including 60 patients with type 2 diabetic nephropathy and 60 patients with type 2 diabetes but without nephropathy matched by sex and age. Polymorphisms of EDN1 rs5370 locus were detected using polymerase chain reaction (PCR) techniques. Results Serum levels of total cholesterol, triglycerides, low-density lipoprotein, creatinine and uric acid were notably elevated in the diabetic nephropathy group compared with the non-nephropathy diabetes group. There was a significant difference in the distribution of the EDN1 rs5370 alleles between the groups. Individuals with T/T genotype had a significantly lower risk of diabetic nephropathy compared to those with G/G genotype [OR=0.357, 95%CI(0.132-0.963), P=0.042]. Additionally, individuals with T allele had a significantly lower risk of diabetic nephropathy compared to those with G allele [OR=0.565, 95%CI(0.339-0.942), P=0.029]. Conclusions The rs5370 polymorphism of EDN1 gene may be associated with the risk of type 2 diabetic nephropathy, especially the T allele may offer a protective effect. These findings provide important insights into the genetic mechanisms of diabetic nephropathy and may influence future strategies for prevention and treatment.
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Received: 16 April 2024
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| [1] |
Wang T. Association between lipoprotein(a) plasma levels and diabetic nephropathy in Han Chinese patients with type 2 diabetes mellitus[J]. PLoS One,2024, 19(5): e0299240.
|
| [2] |
Lenoir O, Milon M, Virsolvy A, et al. Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis[J]. J Am Soc Nephrol,2014, 25(5): 1050-1062.
|
| [3] |
Zanatta C M, Veronese F V, Loreto Mda S, et al. Endothelin-1 and endothelin a receptor immunoreactivity is increased in patients with diabetic nephropathy[J]. Ren Fail,2012, 34(3): 308-315.
|
| [4] |
Lago-Docampo M, Solarat C, Mendez-Martinez L, et al. Common Variation in EDN1 Regulatory Regions Highlights the Role of PPARgamma as a Key Regulator of Endothelin in vitro[J]. Front Cardiovasc Med,2022,9: 823133.
|
| [5] |
Dubovyk Y I, Oleshko T B, Harbuzova V Y, et al. Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population[J]. Dis Markers,2018, 2018: 1695782.
|
| [6] |
Zanatta C M, Crispim D, Sortica D A, et al. Endothelin-1 gene polymorphisms and diabetic kidney disease in patients with type 2 diabetes mellitus[J]. Diabetol Metab Syndr,2015, 7: 103.
|
| [7] |
Li H, Louey J W, Choy K W, et al. EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes[J]. Mol Vis,2008, 14:1698-1704.
|
| [8] |
Maslat A O, Al-Mahmood O M, Al Khawaja N M, et al. Association of Genetic polymorphisms of EDN1 gene and Endothelin-1 level in patients with type 2 diabetes mellitus in the Jordanian population[J]. Heliyon,2024, 10(1): e23676.
|
| [9] |
Biswas S, Feng B, Thomas A, et al. Endothelin-1 regulation is entangled in a complex web of epigenetic mechanisms in diabetes[J]. Physiol Res,2018, 67(Suppl 1): S115-S25.
|
| [10] |
Vargas-Alarcon G, Vallejo M, Posadas-Romero C, et al. The -974C>A (rs3087459) gene polymorphism in the endothelin gene (EDN1) is associated with risk of developing acute coronary syndrome in Mexican patients[J]. Gene,2014, 542(2):258-262.
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2024, Vol. 35 
