富含血小板血浆联合自体骨移植治疗骨缺损的临床研究

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Abstract Objective To evaluate the therapeutic effect of platelet-rich plasma (PRP) combined with autologous bone grafting in the treatment of bone defect and its influence on bone repair. Methods Sixty patients with bone defect admitted to Characteristics Medical Center of PLA Rocket Army from January 2023 to December 2023 were selected as the research subjects, and were divided into two groups according to the random number table method, the experimental group (30 cases) and the control group (30 cases). The experimental group was treated with PRP combined with autologous bone grafting, while the control group was treated with simple autologous bone grafting. The two groups were compared in terms of bone healing time, bone healing rate, bone density, bone strength, bone morphology scoring, LEFS scoring, and VAS scoring. Multivariate linear regression and multivariate logistic regression analyses were used to identify factors influencing bone healing. Results The experimental group showed significantly better outcomes in terms of bone healing time, bone healing rate, bone density, bone strength, and bone morphology scoring compared with the control group, with statistically significant differences (P<0.05), and no serious postoperative complications occurred. Multivariate regression analysis indicated that PRP treatment was an independent influencing factor for bone healing time and bone healing rate (P<0.05). Conclusions PRP combined with autologous bone grafting is a safe, effective, and feasible treatment for bone defect, which can promote the healing and repair of bone defect, improve the quality of bone healing, and enhance patients' quality of life.

Key words： platelet-rich plasma autologous bone grafting bone defect bone repair

Received: 05 January 2024

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	DONG Haijiao
	SHEN Guodong
	HAO Yan
	DU Aicui
	DU Bin

Cite this article:

DONG Haijiao,SHEN Guodong,HAO Yan等. Clinical research of PRP combined with autologous bone grafting in treatment of bone defect[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(6): 506-510.

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https://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR https://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2024/V35/I6/506

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