脾硬化性血管瘤样结节性转化的临床病理特征

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (2503 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinicopathological features of sclerosing angiomatoid nodular transformation(SANT). Methods Clinical data of SANT patients in the Fourth and Sixth Medical Center of PLA General Hospital from 2016 to 2022 were collected, and the clinicopathological features, imaging features and immunohistochemical data were analyzed. Results A total of 7 cases were found, including 5 males and 2 females, aged 32-49 years with an average age of 42.3 years. Six cases were single, with a maximum diameter of 3.0-14.5 cm (average 7.4 cm), and 1 case was multiple, with a maximum diameter of 5.7 cm×5 cm×3.5 cm, with a minimum diameter of 0.7 cm×0.6 cm×0.6 cm. Microscopically, there were multiple hemangiomatous nodules surrounded by fibers. The vascular components in the nodules were complex, which were like splenic sinus, capillary or venous. The expressions of CD34, CD31, and CD8 in vascular endothelial cells were different. The SMA expression in peripheral spindle cells was focally positive. EBER detection results of in situ hybridization were negative. Conclusions SANT is a rare benign vascular lesion with unique pathological features, which has no clinical symptoms and is easy to be misdiagnosed. It can be cured by surgical resection. Postoperative pathological morphology and immunohistochemical staining are important methods for definite diagnosis.

Key words： spleen sclerosing angiomatoid nodular transformation clinical pathology differential diagnosis

Received: 20 February 2024

ZTFLH:

R733.3

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YU Lan
	DING Huizhen
	GAO Yiqun
	LU Ping
	ZHANG Jing

Cite this article:

YU Lan,DING Huizhen,GAO Yiqun等. Clinicopathological features of sclerosing angiomatoid nodular transformation[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(7): 567-571.

URL:

https://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR https://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2024/V35/I7/567

[1]	Martel M, Cheuk W, Lombardi L, et al. Sclerosing angiomatoid nodular transformation (SANT): report of 25 cases of a distinctive benign splenic lesion[J]. Am J Surg Pathol, 2004, 28(10): 1268-1279.
[2]	Vanden S, Voorde N, VanhoenackerF, et al. Sclerosing angiomatoid nodular transformation of the spleen: a diagnostic conundrum [J].J Belg Soc Radiol, 2022, 106(1): 12.
[3]	Silverman M, Livolsi V. Splenic hamartoma[J]. Am J Clin Pathol, 1978, 70(2): 224-229.
[4]	He C, Yang W. Multifocal sclerosing angiomatoid nodular transformation of the spleen with splenomegaly and thrombocytopenia[J]. Balkan Med J, 2022, 39(1): 73-75.
[5]	Auerbach A, Girton M, Aguilera N. Controversies in the spleen: histiocytic, dendritic, and stromal cell lesions[J]. Surg Pathol Clin, 2023, 16(2): 385-400.
[6]	Wang H, Hu B, Chen W, et al. Clinicopathological features of sclerosing angiomatoid nodular transformation of the spleen[J]. Pathol Res Pract, 2021, 224(24): 153490.
[7]	Jonathan S, Robin D. Sclerosing angiomatoid nodular transformation of the pleen [J].Blood, 2021,137(17): 2417.
[8]	Hao T, Cheng H, Yu T. Reappraisal of surgical decision-making in patients with splenic sclerosing angiomatoid nodular transformation: case series and literature review [J].World J Gastrointest Surg, 2021,13(8): 848-858.
[9]	Raffaele G, Francescamaria D, Emanuele F, et al . A splenic IgG4+sclerosing angiomatoid nodular transformation (SANT) treated by hemisplenectomy: a radiologic, histochemical, and immunohistochemical study[J]. Appl Immunohistochem Mol Morphol, 2020, 28(5): e40-e46.
[10]	Jin Y, Gao W, Li F, et al. Is Sclerosing angiomatoid nodular transformation an IgG4-associated sclerosing disease[J]. Appl Immunohistochem Mol Morphol, 2020, 28(2): e18-e20.
[11]	Donald T, Xuchen Z. Calcifying fibrous tumor of the gastrointestinal tract: a clinicopathologic review and update[J].World J Gastroenterol, 2020, 26(37): 5597-5605.
[12]	Kung C, Jen L, Yu W, et al. Polyclonality in sclerosing angiomatoid nodular transformation of the spleen [J].Am J Surg Pathol, 2016, 40 (10): 1343-1351.
[13]	刘周英,杜俊,张劲松,等.脾硬化性血管瘤样结节性转化3例临床病理学分析[J].中华病理学杂志, 2022, 51(8):755- 757.
[14]	叶丹丽,刘映文,赖续文,等.脾硬化性血管瘤样结节性转化6例临床病理分析[J].临床与实验病理学杂志, 2020, 36(11): 1317-1320.
[15]	Kazuki M, Takeshi S, Akio K, et al. A case of sclerosing angiomatoid nodular transformation resected for suspected relapse of diffuse large B-cell lymphoma[J]. Gan To Kagaku Ryoho, 2022, 49(4): 459-461.
[16]	Bee S, Rebecca T. Sclerosing angiomatoid nodular transformation (SANT): a rare splenic tumor and unusual cause of Anemia[J].Am J Case Rep, 2021, 13 (22): e933598.
[17]	Nancy K, Aaron A, Maria A. Algorithmic approach to the splenic lesion based on radiologic-pathologic correlation[J]. Radiographics, 2022, 42(3): 683-701.
[18]	Chen N, Wang M, Wang H, et al. Sclerosing angiomatoid nodular transformation of the spleen: multimodality imaging features and literature review[J]. BMC Med Imaging, 2023, 23(1): 50.
[19]	施云华,何剑,储海瑞.脾硬化性血管瘤样结节性转化的MRI表现与病理对照分析[J].医学影像学杂志, 2020,30(9):1653-1656.
[20]	杨淑辉,李亚卓,钟燕,等.脾脏硬化性血管瘤样结节性转化的CT和MR影像学特点[J].山东医药, 2022, 62(24): 71-73.
[21]	Auerbach A, Girton M, Aguilera N. Controversies in the spleen: histiocytic, dendritic, and stromal cell lesions[J].Surg Pathol Clin, 2023, 16(2): 385-400.