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| Relationship between thyroid hormone levels and frailty in elderly community members |
| LIU Yutong1, CHEN Wei2, GAO Yang3, GUAN Bo4, LIU Ruihan1, YANG Mingyan1, CAO Jian1 |
1. the Fourth Department of Healthcare, National Clinical Research Center for Geriatric Diseases, the Second Medical Center of PLA General Hospital,Beijing 100853,China;
2. Outpatient Department, the 16th Recreation Center for Retired Cadres in Fengtai District of Beijing Garrison, Beijing 100071,China;
3. Outpatient Department, the 55th Recreation Center for Retired Cadres in Haidian District of Beijing Garrison,Beijing 101199,China;
4. Department of Geriatrics, Suzhou Municipal Hospital, Suzhou 215002, China |
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Abstract Objective To analyze the relationship between thyroid hormones (THs), frailty and the five components of frailty phenotype (fatigue, resistance, walking ability, number of illnesses, and weight loss) in the elderly. Methods Cross-sectional study with 487 community-dwelling elderly residents aged ≥80 years was conducted. A clear diagnosis of frailty was made based on the FRAIL scale (fatigue, resistance, walking, disease, and weight loss), and positive scores were recorded for each frailty subdomain. Demographic information (age, sex, marital status and education), comorbidities, and details of the participants’ lifestyles were also recorded. Laboratory tests were performed to determine serum THs, including free triiodothyronine (fT3), triiodothyronine (T3), free thyroxine (fT4), and thyroxine (T4), and thyroid stimulating hormone (TSH) levels. logistic regression of the data was performed to screen out potential risk factors for frailty and its subdomains. Results Of the 487 subjects enrolled, 60 (12.23%) were diagnosed with subclinical hypothyroidism, and 110 (22.59%) had a positive frailty score. Logistic regression analysis adjusted for all potential confounders showed that frailty was significantly associated with serum TSH concentration (OR:1.06), fT3 concentration (OR:0.54), and subclinical hypothyroidism (OR:2.18).The study showed no association between fT4 and frailty, whereas fT3/fT4 was associated with frailty. Conclusions Subclinical hypothyroidism, higher TSH levels, lower fT3 levels, and lower fT3/fT4 ratio are all associated with frailty as assessed by the FRAIL scale in community-dwelling elderly. Future longitudinal studies are needed to continue to determine the association between thyroid dysfunction and frailty in the elderly.
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Received: 28 November 2023
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2024, Vol. 35 
