脑卒中后癫痫患者采用重复经颅刺激干预的临床效果

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Abstract Objective To investigate the clinical effect of repetitive transcranial magnetic stimulation (rTMS) in patients with epilepsy after stroke. Methods A total of 104 patients with post-stroke epilepsy treated in the Second Medical Center of PLA General Hospital from January 2021 to March 2023 were divided into observation group (n=52) and control group (n=52) using envelope method. The control group received routine treatment, while the observation group received rTMS treatment on the basis of the control group. The therapeutic effect and seizure status of the two groups were observed. Results The total effective rate of the observation group was 96.15%, which was better than that of the control group (P<0.05). After treatment, the frequency and duration of attacks in the observation group were (1.01±0.27) times/month and (2.20±0.74) min/time, respectively, which were lower than those in the control group (P<0.05). The Mini-mental State Examination (MMSE) score of the observation group after treatment was (25.54±2.01), which was higher than that of the control group (P<0.05), while the National Institutes of Health Stroke Scale (NIHSS) score was (6.14±1.82), which was lower than that of the control group (P<0.05). The scores of social function, physical function, psychological function, and material function on the GQOL-74 comprehensive assessment questionnaire for quality of life after treatment in the observation group were (86.65±9.55) points, (72.82±8.02) points, (80.03±8.33) points, and (83.34±7.94) points, respectively, which was higher than those in the control group (P<0.05). After treatment, serum homocysteine (Hcy), S100 calcium binding protein B (S100B), and neuron specific enolase (NSE) in the observation group were (7.22±1.93) μmol/L, (0.30±0.18) μg/L, and (5.65±1.12) μg/L, respectively, which were lower than those in the control group (P<0.05). Conclusions rTMS intervention has a good effect on patients with epilepsy after stroke, which is beneficial to the control of epilepsy and can improve the neurological and cognitive functions of the patients.

Key words： stroke epilepsy repetitive transcranial magnetic stimulation clinical effect cognitive functions

Received: 03 February 2024

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	LI Xuefeng
	WANG Yingzhao
	SUN Bo
	CUI Yanwen

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LI Xuefeng,WANG Yingzhao,SUN Bo等. Clinical effect of repetitive transcranial magnetic stimulation in patients with epilepsy after stroke[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(10): 880-884.

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https://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR https://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2024/V35/I10/880

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