循环肿瘤DNA对食管恶性肿瘤预后评估价值的Meta分析

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Abstract Objective To explore the clinical application value of circulating tumor DNA (ctDNA) in prognostic evaluation of esophageal malignancies. Methods Pubmed, Cochrane Library, Embase and Web of Science databases were used to search articles discussing the clinical application value of ctDNA in the prognosis assessment of esophageal malignancies from the establishment of the database to November 24, 2022. Two researchers independently searched the database, screened the literature, extracted and analyzed the data, analyzed the risk of bias in the included literature, extracted the risk ratio (hr) of disease-free survival (DFS) and overall survival (OS), and used Revman 5.3 for statistical analysis. Chi-square test was used to calculate the heterogeneity among the combined results. Results A total of 321 patients were included in this study, among which 8 studies were included in the PFS meta-analysis of ctDNA prediction of esophageal malignancies. he heterogeneity of progression-free survival (PFS) in patients with esophageal malignancies was low (I²=28%, P>0.05), so the fixed-effect model was used (HR=4.14, 95%CI :2.65~6.47, P<0.05). The results showed that ctDNA-positive patients were associated with poor PFS. In the meta-analysis of ctDNA’s prediction of overall survival (OS) in patients with esophageal malignancies, a total of 4 studies were included, with low heterogeneity(I²=15%, P>0.05). Using a fixed-effect model, CtDNA-positive patients had worse prognosis than ctDNA-negative patients with OS(HR=4.71, 95%CI: 2.78~7.97, P<0.05). Conclusions Tumor-associated ctDNA detection is expected to become an auxiliary prognostic measure for patients with esophageal malignancies.

Key words： esophageal malignancy ctDNA Meta-analysis

Received: 14 May 2024

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	LIU Hong
	BIAN Xiaoshan
	CUI Yimeng
	SUN Leilei
	LI Ruiyang

Cite this article:

LIU Hong,BIAN Xiaoshan,CUI Yimeng等. Meta-analysis of prognostic value of ctDNA in esophageal malignancies[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2025, 36(1): 12-15.

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https://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR https://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2025/V36/I1/12

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