病毒性心肌炎患者血清钙卫蛋白A4、A8/A9与病情及预后不良的关系

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Abstract Objective To investigate the relationship between serum calprotectin A4 (S100A4), calprotectin A8/A9 (S100A8/A9) and disease condition and poor prognosis in patients with viral myocarditis (VMC). Methods A total of 151 VMC patients admitted to Guangdong Provincial Corps Hospital of Chinese People's Armed Police Force from November 2020 to November 2022 were divided into a mild group (87 cases) and a severe group (64 cases) according to the severity of the disease. During the same period, 90 healthy volunteers who underwent physical examination in the same hospital were selected as a healthy group. The baseline data and serum S100A4 and S100A8/A9 expression levels in the three groups at admission were compared. All VMC patients were followed up for 1 year, and divided into poor prognosis group and good prognosis group according to the occurrence of adverse events. The influencing factors affecting the poor prognosis of VMC were analyzed by multivariate Logistic analysis, the predictive efficacy of serum S100A4 and S100A8/A9 on the poor prognosis of patients was analyzed by receiver operating characteristic (ROC) curve. Results The levels of serum S100A4 and S100A8/A9 in mild and severe groups were higher than those in healthy group (P＜0.05), and the levels of serum S100A4 and S100A8/A9 in severe group were higher than those in mild group (P＜0.05). Compared with the good prognosis group, the poor prognosis group showed an increase in the proportion of atrioventricular block, cardiac troponin I, creatine kinase isoenzyme, serum S100A4, and serum S100A8/A9 levels (P＜0.05), and a decrease in left ventricular ejection fraction (P＜0.05). Atrioventricular block (OR=1.850,95%CI:1.369-2.511), elevated cardiac troponin I (OR=1.738,95%CI:1.285-2.306), elevated creatine kinase isoenzyme (OR=1.677,95%CI:1.213-2.127), elevated S100A4 (OR=1.409,95%CI:1.021-1.869), and elevated S100A8/A9(OR=1.493,95%CI:1.115-1.936) were risk factors for poor prognosis of VMC, while elevated left ventricular ejection fraction (OR=0.627,95%CI:0.558-0.815) was a protective factor (P＜0.05). ROC curve results showed that the AUC of serum S100A4 and S100A8/A9 to predict the poor prognosis of VMC was 0.675 and 0.719, respectively. The AUC of combining serum S100A4 and S100A8/A9 to predict the poor prognosis of VMC was 0.784, which was greater than that of S100A4 or S100A8/A9 alone. Conclusions The high expression of serum S100A4 and S100A8/A9 is related to the aggravation of VMC and the occurrence of poor prognosis in VMC patients. The combined detection of the two indicators can improve the prediction efficiency of poor prognosis in patients.

Key words： viral myocarditis calprotectin A4 calprotectin A8/A9 prognosis predictive value

Received: 09 August 2024

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	SUN Minyi
	HUANG Yan
	LIN Gengying

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SUN Minyi,HUANG Yan,LIN Gengying. Relationship between serum calprotectin A4, A8/A9 and disease condition and poor prognosis in patients with viral myocarditis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2025, 36(2): 110-114.

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https://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR https://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2025/V36/I2/110

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