消化内镜OLGA分级联合血清miR-760对幽门螺杆菌阳性慢性萎缩性胃炎癌变的诊断效能

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Abstract Objective To evaluate the efficacy of the combined use of endoscopic OLGA grading and serum miR-760 in the diagnosis of canceration of Helicobacter pylori (Hp) positive chronic atrophic gastritis(CAG). Methods According to the results of endoscopic diagnosis and histopathological examination, 100 patients with Hp-positive CAG admitted to Shanxi Provincial Corps Hospital of Chinese People's Armed Police Force from September 2022 to September 2023 were divided into CAG group (61 cases) and canceration group (39 cases). The clinical data, digestive endoscopy OLGA grading, serum miR-760, and the score of the new gastric cancer screening scoring system were compared between the two groups. Multivariate logistic regression analysis was used to explore the independent risk factors related to Hp-positive CAG cancer, and receiver operating characteristic curve (ROC) was used to analyze the value of different schemes in the diagnosis of Hp-positive CAG cancer risk. Results The severity of Hp infection in the canceration group was higher than that in the CAG group, and the scores of endoscopic OLGA and the new gastric cancer screening scoring system were higher than those in the CAG group, while the miR-760 level was lower than that in the CAG group (P＜0.05). Multivariate logistic regression analysis showed that the OLGA grade IV and the increased score of the new gastric cancer screening scoring system were independent risk factors for Hp-positive CAG cancer, while the increased level of miR-760 was an independent protective factor for the carcinogenesis of Hp-positive CAG (P＜0.05). ROC curve showed that the combined use of endoscopic OLGA grading and serum miR-760 was significantly higher than endoscopic OLGA grading and serum miR-760 alone (P＜0.05). The AUC of the combined use of the OLGA classification of digestive endoscopy and serum miR-760 was significantly higher than that of the new gastric cancer screening scoring system (P＜0.05). The consistency analysis of Kappa value showed that the diagnostic accuracy of Hp-positive CAG canceration using the combined method of endoscopic OLGA classification and serum miR-760 was 91.67% in clinical practice, with a Kappa value of 0.805 (95% CI: 0.552-1.058) (P＜0.05). Conclusions The combination of the OLGA grading of digestive endoscopy and serum miR-760 can significantly improve the diagnostic efficacy of canceration in Hp-positive CAG patients, providing important reference information for clinical precision identification of high-risk populations, precise intervention, and reduction of the incidence of gastric cancer.

Key words： digestive endoscopy OLGA grading miR-760 Hp-positive chronic atrophic gastritis canceration diagnostic efficiency

Received: 11 November 2024

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	GAO Li
	YAN Ruifeng
	KAN Weijun

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GAO Li,YAN Ruifeng,KAN Weijun. Efficacy of OLGA grading of digestive endoscopy combined with serum miR-760 in diagnosis of canceration of Hp-positive chronic atrophic gastritis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2025, 36(3): 185-189.

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https://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR https://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2025/V36/I3/185

[1]	Wang P, Li P, Chen Y,et al. Chinese integrated guideline on the management of gastric precancerous conditions and lesions[J]. Chin Med, 2022, 17(1): 138.
[2]	中华医学会肿瘤学分会,中华医学会杂志社.中华医学会胃癌临床诊疗指南(2021版)[J].中华医学杂志,2022,102(16):1169-1189.
[3]	Fang S, Liu Z, Qiu Q, et al. Diagnosing and grading gastric atrophy and intestinal metaplasia using semi-supervised deep learning on pathological images: development and validation study[J].Gastric Cancer,2024,27(2):343-354.
[4]	Carlosama Y H, Acosta C P, Sierra C H, et al. The operative link on gastritis assessment(OLGA) system as a marker for gastric cancer and dysplasia in a Colombian population at risk: a multicenter study[J].Biomedica, 2023, 43(3):30-40.
[5]	董文珠,梁越,赵琦,等.胃黏膜“血清学活检”在胃癌前疾病筛查中的临床应用[J].中国临床研究,2023,36(2):186-190.
[6]	张琳,谭劲,刘一平,等.姜黄素通过调控HIF-1α/miR-760/LTBP2机制轴抑制口腔黏膜下纤维化的效果研究[J].中医药导报,2024,30(1):1-4.
[7]	贾龙江,郝斌,许长宝,等.长链非编码RNA FOXD2相邻相反链RNA 1靶向调控微小RNA-760对前列腺癌细胞增殖和凋亡的影响[J].安徽医药, 2022, 26(6):1183-1187.
[8]	袁生武,陈娟,刘凯. miR-760抑制人食管鳞状细胞癌细胞系的增殖、侵袭和迁移[J].基础医学与临床,2022,42(11):1697-1703.
[9]	Dixon M F, Genta R M, Yardley J H, et al. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994[J].Am J Surg Pathol,1996,20(10):1161-1181.
[10]	Rugge M, Genta R M, Malfertheiner P, et al. RE.GA.IN.: the real-world gastritis initiative-updating the updates[J].Gut,2024,73(3):407-441.
[11]	Papp V, Miheller P. Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda[J]. World J Gastroenterol,2024,30(17):2308-2310.
[12]	Huang R J, Laszkowska M, In H, et al. Controlling gastric cancer in a world of heterogeneous risk[J].Gastroenterology,2023,164(5):736-751.
[13]	Tziatzios G, Ziogas D Ι, Gkolfakis P, et al. Endoscopic grading and sampling of gastric precancerous lesions: a comprehensive literature review [J]. Curr Oncol, 2024,31(7): 3923-3938.
[14]	Shah S, Piazuelo M B, Kuipers E J, et al. AGA clinical practice update on the diagnosis and management of atrophic gastritis: expert review [J]. Gastroenterology, 2021,161(4):1325-1332.
[15]	王霄腾,韩丰,王超,等.OLGA胃炎评价标准在胃黏膜癌前状态和癌前病变风险评估中的价值[J].中华医学杂志, 2022, 102(12): 853-857.
[16]	Zhou Y, Li H Y, Zhang J J, et al. Operative link on gastritis assessment stage is an appropriate predictor of early gastric cancer[J]. World J Gastroenterol, 2016, 22(13): 3670-3678.
[17]	Rugge M, Genta R M, Fassan M, et al. OLGA gastritis staging for the prediction of gastric cancer risk: a long-term follow-up study of 7436 patients[J].Am J Gastroenterol,2018,113(11):1621-1628.
[18]	Nagula S, v Parasa S, Laine L, et al. AGA clinical practice update on high-quality upper endoscopy: expert review[J].Clin Gastroenterol Hepatol,2024,22(5):933-943.
[19]	Jiao Y, Zhang L, Li J, et al. Exosomal miR-122-5p inhibits tumorigenicity of gastric cancer by downregulating GIT1[J]. Int J Biol Markers, 2021, 36(1):36-46.
[20]	Lee S, Cho M, Park B, et al. Finding miRNA-RNA network biomarkers for predicting metastasis and prognosis in cancer[J]. Int J Mol Sci,2023,24(5):5052.
[21]	Qian Z, Xin H, Jia Z, et al. MiR-760 exerts a critical regulatory role in glioma proliferation, migration, and invasion by modulating MMP2 expression[J].J Cancer,2024,15(10):3076-3084.
[22]	牛正宣,周丽,周大新.miR-760靶向调节黑色素瘤抗原家族D1抑制胃癌细胞增殖、迁移及侵袭的研究[J].中国临床药理学杂志, 2023, 39(4): 493-497.
[23]	Ge L, Wang Y, Duan Q H, et al. MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription[J].World J Gastroenterol, 2019, 25(45): 6619-6633.
[24]	Liu W, Li Y, Feng S, et al. MicroRNA-760 inhibits cell viability and migration through down-regulating BST2 in gastric cancer[J]. J Biochem, 2020, 168(2): 159-170.
[25]	石振旺,方东,鲍德明,等.新型胃癌筛查评分系统和OLGA分级在慢性萎缩性胃炎癌变风险分层中的一致性评价[J].中国老年学杂志,2023,43(15):3649-3652.