Abstract： Objective To study the value of urine AD7c-NTP levels for the early diagnosis of Alzheimer disease (AD). Methods Using enzyme linked immunosorbent assay (ELISA), the urine AD7c-NTP level was determined and compared: (1)Thirty-eight patients with dementia & 35 age-matched healthy persons; (2) the levels of urine AD7c-NTP & the scores of MMSE, CDR, ADL. Results The urine AD7c-NTP of AD group and the normal group were（90.78±16.54）ng/ml,（70.63±12.56）ng/ml, respectively. Compared with the normal mental group, the levels of urine AD7c-NTP in AD group were significantly increased (P＜0.05), which was negatively correlated with the scores of MMSE (the examination of mental state), CDR (clinical dementia rating scale) and ADL (activities of daily living scale).The correlations between AD7c-NTP and MMSE (r=0.756), AD7c-NTP and CDR (r=-0.658), and AD7c-NTP and ADL (r=-0.760）were significant in AD patients (all P<0.01).Conclusions Urine AD7c-NTP levels may be an important biochemical marker for the early diagnosis and condition assessment of AD.
Zhang Z X, Zahner G E, Román G C, et al. Socio-de mographic variation of dementia subtypes in china: methodology and results of a prevalence study in Beijing, Chengdu, Shanghai, and Xian ［J］. Neuroepidemiology, 2006, 27(4):177-187.
［1］
Zhang Z X, Zahner G E, Román G C, et al. Socio-de mographic variation of dementia subtypes in china: methodology and results of a prevalence study in Beijing, Chengdu, Shanghai, and Xian ［J］. Neuroepidemiology, 2006, 27(4):177-187.
[2]
Diniz B S, Pinto Júnior J A, Forlenza O V. Do CSF total tau, phosphorylated tau, and beta-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease? A systematic review and meta-analysis of the literature ［J］. World J Biol Psychiatry, 2008, 9(3):172-182.
[2]
Diniz B S, Pinto Júnior J A, Forlenza O V. Do CSF total tau, phosphorylated tau, and beta-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease? A systematic review and meta-analysis of the literature ［J］. World J Biol Psychiatry, 2008, 9(3):172-182.
[3]
De la Monte S M, Wands J R. Neurodegeneration changes in primary central nervous system neurons transfected with the Alzheimer-associated neuronal thread protein gene ［J］. Cell Mol Life Sci, 2001, 58(5-6): 844-849.
[3]
De la Monte S M, Wands J R. Neurodegeneration changes in primary central nervous system neurons transfected with the Alzheimer-associated neuronal thread protein gene ［J］. Cell Mol Life Sci, 2001, 58(5-6): 844-849.
[4]
World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines.1992.
[4]
World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines.1992.
[5]
Forlenza O V, Diniz B S, Gattaz W F. Diagnosis and biomarkers of predementia in Alzheimer's disease ［J］. BMC Med, 2010, 8: 89.
[5]
Forlenza O V, Diniz B S, Gattaz W F. Diagnosis and biomarkers of predementia in Alzheimer's disease ［J］. BMC Med, 2010, 8: 89.
[6]
Munzar M, Levy S, Rush R, et al. Clinical study of a urinary competitve ELISA for neural thread protein in Alzheimer disease ［J］. Neurol Clin Neurophysiol, 2002 (1): 2-8.
Munzar M, Levy S, Rush R, et al. Clinical study of a urinary competitve ELISA for neural thread protein in Alzheimer disease ［J］. Neurol Clin Neurophysiol, 2002 (1): 2-8.
Goodman I, Golden G, Flitman S, et al. A multi-center blinded prospective study of urine neural thread protein measurements in patients with suspected Alzheimer's disease ［J］. J Am Med Dir Assoc, 2007, 8(1): 21-30.
Goodman I, Golden G, Flitman S, et al. A multi-center blinded prospective study of urine neural thread protein measurements in patients with suspected Alzheimer's disease ［J］. J Am Med Dir Assoc, 2007, 8(1): 21-30.
2012, Vol. 23 
