1.Department of Endocrinology,The 309 Hospital of Chinese People’s Liberation Army.Beijing 100091,China;
2. Centers for disease control and prevention of CAPF. Beijing 102613 ,China;
3.Department of Endocrinology,The Fourth Military Medical University of PLA. Xi’an 710032 ,China
Abstract：Objective To discuss the clinical implications of urinary β2 microglobulin(U-β2-MG)and its related factors in T2 Diabetes Mellitus patients with diabetic nephropathy(DN). Methods We collected 171 diagnosed DN patients (male 109, female 62). Correlation analysis of U-β2-MG and the other clinical test items was made. Correlation analysis was made again after we divided patients into three groups: simple DM , DM with hypertension, DM with hypertension and hyperlipidemia. Results Positive correlation between levels of U-β2-MG and indices as A1β, IgG, a1-MG, level of SCr and SBP was found. Within group DM, levels of U-β2-MG had an significantly positive correlation with levels of CHO、HDL、BUN, while showing negative correlation with GFR. In the group of DM with hypertension, there was a positive correlation with levels of U-β2-MG and those of SBP,CHO,LDL,SCr, and a negative correlation with GFR . In the last group, there was an significantly positive correlation between levels of U-β2-MG and DBP,LDL,BUN,and still a negative correlation with level of U-β2-MG and GFR. Conclusions Damage of Tubule interstitial is easily found in DN patients. U-β2-MG was negatively correlated with GFR, indicating that U-β2-MG has already increased when GFR slightly decreased. The produce of U-β2-MG is closely related to the level of blood glucose ,blood pressure, and lipid level. U-β2-MG was significantly associated with CHO, LDL-C, SCr, which showed that early active control of blood lipid might have positive effects on the prognosis of DN, especially in aspect of avoiding renal tubular damage.
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2013, Vol. 24 
