1.Xuzhou Medical College,Xuzhou 221004,China; 2..Department of Neurology. General Hospital of Chinese People’s Armed Police Forces, Beijing 100039,China
Abstract：Objective To investigate the predictive function of treadmill stress test in statin-related myopathy(SRM), and to study whether the heat shock protein family would be the predictive factors for SRM. Methods Fifty-seven patients who were eligible for statins signed informed consents. The treadmill stress test was done as follows: patients treaded at a certain condition (reach 65%±5% of their maximum heart rate) for three 15-minnte periods with 10 minutes of rest between exercise bouts. Before, 5 days and 10 days after statin administration, blood sampling was done before and immediately after treadmill stress test. All the procedures were performed fasting in the morning. Then the serum levels of liver function, lipids, CK, HSP25, HSP70 and Cry-αB in the blood samples were tested. All the patients were followed up for 6 months. Patients who had the symptoms that could not be explained by other causes were divided into the SRM group, while the rest into the non-SRM group. The correlation between SRM group and non-SRM group was analysed with SPSS 16.0. Results Compared with CK before treadmill stress test without statin administration, CK after treadmill stress test with statin administration for 5 days CK increased by (46.08±5.61) U/L in SRM group, which was much higher than that in non-SRM group (14.98±2.44) U/L, with significant difference (P＜0.05). HSP70, after treadmill stress test with statin administration for 5 days increased by (0.16±0.04) ng/ml, compared with that before treadmill stress test without statin administration in SRM group, while it only increased by (0.02±0.03) ng/ml in non-SRM group, and the difference between the two groups was significant(P＜0.05). However, the changes in HSP 25 and Cry-αB at different time points between the two groups were not significantly diffcrent (P＞0.05).Conclusions The treadmill stress test may predict the statin-related myopathy to some extent, and HSP 70 may be associated with SRM.
2013, Vol. 24 
