Significance of detecting circulating tumor cells in peripheral blood of postoperative patients with non-small cell lung cancer
DU Kaiqi1,ZHU Youcai1,YANG Yong2,ZHANG Zhihao1,XU Zhuhui1,and LI Xiaofeng1.
1.Department of Cardiothoracic Surgery, 2.Department of Clinical Iaboratory, Zhejiang Provincial Corps Hospital,Chinese People’s Armed Police Forces, Jiaxing 314000, China
Abstract：Objective To investigate the significance of detecting circulating tumor cells(CTCs) in peripheral blood of postoperative patients with non-small cell lung cancer(NSCLC). Methods Thirty-eight patients with lung adenocarcinoma diagnosed by pathology and treated by radical surgery, were staged by TNM staging criteria,including stage Ⅰ 19 cases, stage Ⅱ 6 cases, and stage Ⅲ 13 cases. Ten patients with lung benign disease served as control group; they were diagnosed by postoperative pathology(4 cases with tuberculosis, 6 cases with lung inflammatory lesions). CTCs in peripheral blood(every 7.5 ml)were detected by the method of immune magnetic bead-based rare cell enrichment system combined with flow cytometry. Results The positive rate of peripheral blood CTCs was 10%(1/10)in lung benign disease patients and 39.5% (15/38) in NSCLC patients. There was no difference in CTCs positive rate between lung benign disease patients and NSCLC patients(P=0.132).There was difference in CTCs positive rate between Ⅰ stage patients and Ⅲ stage patients(χ2=3.970,P=0.046). Conclusions CTCs can be detected in peripheral blood of postoperative NSCLC patients and can be used to guide the therapy.The positive rate of CTCs is related to TNM staging.
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2013, Vol. 24 
