老年男性患者血清脂蛋白(a)水平与五种代谢性疾病的关系

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (367 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨老年男性患者血清脂蛋白(a)[lipoprotein(a),LP(a)]水平变化与五种代谢性疾病之间的关系,为老年男性患者疾病的诊治提供依据。方法以2011-06至2012-12在武警总医院住院的442例老年男性患者为研究对象,随机抽取同期健康体检老年男性80例为对照组,应用胶乳凝集比浊法测定观察血清LP(a)变化。结果对照组血清LP(a)水平为(154±110)mg/L,在高血压、糖尿病、冠心病、脑梗死及肾功能不全组则分别为(255±191)mg/L、(266±174)mg/L、(341±342)mg/L、(335±277)mg/L、(296±235)mg/L,较对照组明显升高,差异均有统计学意义(P＜0.05);对照组患者LP(a)异常比例为6.3%,在高血压、糖尿病、冠心病、脑梗死及肾功能不全组则分别为25.7%、38.9%、52.4%、42.3%、37.2%,较对照组明显升高,差异均有统计学意义(P＜0.05);按照年龄分组,60~69岁、70~79岁、≥80岁患者各年龄组LP(a)水平无统计学意义。结论血清LP(a)升高参与老年男性患者高血压、糖尿病、冠心病、脑梗死及肾功能的病理过程,该变化与年龄段无关。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	李涛仪
	赵海滨
	王丹
	李凯
	杨长春

关键词 ：老年男性, 疾病, 脂蛋白(a), 水平

Abstract：Objective To investigate the level changes of serum lipoprotein(a),further to provide the evidence for early diagnosis in the elderly male patients. Methods 442 hospitalized elderly male patients between June 2011 and December 2012 were enrolled in this study. Other 80 healthy elderly male subjects served as control group. The levels of serum Lp(a) were measured by latex agglutination turbidimetric method. Results Compared with the control group, the level of Lp(a) was significantly increased in disease group( P＜0.05 ),the levels of Lp (a) in control group was(154±110)mg/L,the level of Lp (a) in the high blood pressure,diabetes mellitus,coronary heart disease,cerebral infarction and renal insufficiency group respectively were(255±191),(266±174),(341±342),(335±277), and (296±235)mg/L respectively. The abnormal ratio in control serum was 6.0%, the abnormal ratios in the high blood pressure, diabetes mellitus, coronary heart disease,cerebral infarction, and renal insufficiency groups were 25.7%, 38.9%, 52.4%, 42.3%, and 37.2 %, respectively; the differences were statistically significant as compared with the control group (P＜0.05). The LP (a) levels of age group were no statistical difference. Conclusions The levels of serum LP (a) are significantly increased in elderly male patients with high blood pressure,diabetes,coronary heart disease,cerebral infarction, and renal insufficiency, regardless of age.

Key words： elderly male patients diseases lipoprotein(a) level

收稿日期: 2014-07-05

ZTFLH:

R592

通讯作者: 杨长春,E-mail:yangchangchun99@sina.com E-mail: litaoyi@sina.com

作者简介: 李涛仪,本科学历,副主任医师

引用本文:

李涛仪,赵海滨,王丹,李凯,杨长春. 老年男性患者血清脂蛋白(a)水平与五种代谢性疾病的关系[J]. 武警医学, 2014, 25(11): 1105-1106. LI Taoyi,ZHAO Haibin,WANG Dan, LI Kai,and YANG Changchun. Relationship between serum lipoprotein(a) levels and five disease in the elderly male patients. Med. J. Chin. Peop. Armed Poli. Forc., 2014, 25(11): 1105-1106.

链接本文:

http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2014/V25/I11/1105

[4]	Mahir K, Wolfgang K. Lipoprotien(a) and cardiometabolic diseases: the mystery continues [J]. Clin Chem, 2010, 56: 1207-1209.
[1]	成水芹,李雷婷,李冰.脂蛋白(a)导致肾损害机制的研究进展 [J]. 中国中西医结合肾病杂志,2012,13(2):186-187.
[2]	Samia M, Pia R K, Nader R, et al. Lipoprotien(a) and risk of teyp2 diabetes [J]. Clin Chem,2010,56: 1252-1260.
[5]	赵剑平,庞兴学,罗智,等. 血清脂蛋白(a)与老年冠心病、高血压的相关性研究 [J]. 中国实用医药,2010,5(23):32-33.
[3]	杨长春,赵海滨,高敏. 老年肺部感染与脂蛋白水平关系的临床研究 [J]. 中华医院感染学杂志,2012,22(13):2799-2801.
[6]	魏建威,朱爱兰. 某市城区居民血清脂蛋白(a)测定结果分析 [J]. 国际检验医学杂志,2012,33(1):75-76.
[4]	Mahir K, Wolfgang K. Lipoprotien(a) and cardiometabolic diseases: the mystery continues [J]. Clin Chem, 2010, 56: 1207-1209.
[7]	张景霞,庄民佗,吴丽娟. 2型糖尿病肾病患者脂蛋白(a)的临床应用价值[J]. 临床检验研究,2012,33(1):38-39.
[5]	赵剑平,庞兴学,罗智,等. 血清脂蛋白(a)与老年冠心病、高血压的相关性研究 [J]. 中国实用医药,2010,5(23):32-33.
[8]	Kotani K, Yamada S, Yamada T, et al. The relationship between oxidized lipoprotein(a) and carotid atherosclerosis in asymptomatic subjects: a comparison with native lipoprotein(a) [J]. Lipids Health Dis, 2011,10(1):174.
[6]	魏建威,朱爱兰. 某市城区居民血清脂蛋白(a)测定结果分析 [J]. 国际检验医学杂志,2012,33(1):75-76.
[9]	李振洲,杨长春,黄佳佳,等. 血清脂蛋白(a)水平与冠心病和脑梗死的相关性探讨 [J].武警医学,2013,24(6):468-470.
[7]	张景霞,庄民佗,吴丽娟. 2型糖尿病肾病患者脂蛋白(a)的临床应用价值[J]. 临床检验研究,2012,33(1):38-39.
[10]	Enkhmaa B, Anuurad E, Zhang W, et al. Lipoprotein(a): genotype-phenotype relationship and impact on atherogenic risk [J]. Metab Syndr Relat Disord, 2011,9(6):411-418.
[8]	Kotani K, Yamada S, Yamada T, et al. The relationship between oxidized lipoprotein(a) and carotid atherosclerosis in asymptomatic subjects: a comparison with native lipoprotein(a) [J]. Lipids Health Dis, 2011,10(1):174.
[9]	李振洲,杨长春,黄佳佳,等. 血清脂蛋白(a)水平与冠心病和脑梗死的相关性探讨 [J].武警医学,2013,24(6):468-470.
[10]	Enkhmaa B, Anuurad E, Zhang W, et al. Lipoprotein(a): genotype-phenotype relationship and impact on atherogenic risk [J]. Metab Syndr Relat Disord, 2011,9(6):411-418.