维生素D<sub>3</sub>对妊娠糖尿病炎性因子及胰岛素抵抗的影响

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摘要目的探讨妊娠糖尿病(gestational diabetes mellitus,GDM)患者应用维生素D₃后,对体内炎性因子水平及胰岛素抵抗的影响。方法选择我院GDM患者60例,随机等量分为对照组(基础治疗)30例,观察组(基础治疗加维生素D₃)30例。观察组在对照组治疗基础上给予口服维生素D₃ 1000 U/d,疗程4周,比较2组治疗前后高敏C反应蛋白(high-sensitivity c-reactive protein,Hs-CRP)、肿瘤坏死因子α(tumor necrosis factor alpha,TNF-α)及胰岛素抵抗变化。结果观察组治疗后hs-CRP较对照组明显降低[(3.80±1.60) mg/L vs (5.05±1.90) mg/L],差异有统计学意义(P<0.05)。观察组治疗后TNF-α较对照组明显降低[(27.45±5.01) pg/ml vs (35.35±14.50) pg/ml],差异有统计学意义(P<0.05)。治疗后观察组胰岛素抵抗较对照组改善明显,差异有统计学意义(P<0.05)。结论较高的血维生素D₃水平可能通过增加胰岛素敏感性,改善妊娠期糖代谢。

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关键词 ：妊娠糖尿病, 高敏C反应蛋白, 肿瘤坏死因子α, 胰岛素抵抗

Abstract：Objective To explore the effect of Vitamin D₃ in gestational diabetes inflammation factor. Methods Sixty patients with gestational diabetes were randomly divided into two groups:30 cases of control group (treatment group), 30 cases of observation group (foundation treatment group plus vitamin D3). On the basis of the control group, treatment observation group was given oral vitamin D₃ 1000 U/d for 4 weeks. Before and after treatment, high-sensitivity c-reactive protein (Hs-CRP), tumor necrosis factor alpha and insulin resistance were compared between two groups. Results Before and after treatment ,observation group hs-CRP (mg/L) was decreased obviously, respectively 6.18±2.99,3.80±1.60; control group was 5.78±2.24, 5.05±1.90. There was statistically significant difference (P<0.05). Before and after treatment ,observation group TNF-α(pg/ml) was decreased obviously, respectively 36.33±5.45,27.45±5.01;control group was 40.25±19.25,35.35±14.50. There was statistically significant difference (P<0.05).After treatment, insulin resistance of observation group was improved (P<0.05). Conclusions High Vitamin D₃ level in blood can improve glucose metabolism during pregnancy through increasing insulin sensitivity.

Key words： gestational diabetes mellitus hs-CRP TNF-α insulin resistance

收稿日期: 2014-07-22

ZTFLH:

R714.256

基金资助:河北省秦皇岛市科技支撑计划项目(201302A089)

作者简介: 侯雪晶,硕士,主治医师

引用本文:

侯雪晶,路春梅. 维生素D₃对妊娠糖尿病炎性因子及胰岛素抵抗的影响[J]. 武警医学, 2014, 25(12): 1245-1247. HOU Xuejing and LU Chunmei. Research on the therapeutic effect of Vitamin D₃ in gestational diabetes factor. Med. J. Chin. Peop. Armed Poli. Forc., 2014, 25(12): 1245-1247.

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http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2014/V25/I12/1245

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