Expression and significance of S-100 and GFAP in lacrimal adenoid cystic carcinoma
WANG Leifeng1, DONG Yuping1, ZHU Sufang1, LI Xiaojuan1, DONG Qiuyan1,and HEI Yan2
1.Department of Ophthalmology, Beijing Municipal Corps Second Hospital, Chinese People’s Armed Police Forces, Beijing 100037, China; 2.The Institute of Orbital Disease ,The General Hospital of Chinese People’s Armed Police Forces, Beijing 100039,China
Abstract：Objective To investigate the expression of Schwann's cell markers S-100 and GFAP in lacrimal adenoid cystic carcinoma, and to explore the relationship between GFAP or S-100 expression and neural invasion of adenoid cystic carcinoma. Methods Twenty-eight lacrimal adenoid cystic carcinoma and 9 normal lacrimal gland specimens were collected . Each specimen was stained by S-P(streptavidin/peroxidase) immuno- histochemical staining. The expression of S-100 and GFAP was analyzed by immunohistochemistry in order to find the difference in the above-mentioned tissues. One-way ANOVA, Student,s test, chi-square test or linear correlation were carried out for statistical evaluation. Results The average S-100 Index(S-100LI) in nor-neural invasion group and neural invasion group were 0.62±1.19 and 16.73±24.74,respectively,in lacrimal gland adenoid cystic carcinoma. (P<0.05). The average GFAP LI in nor-neural invasion group and neural invasion group were 0 and 2.07±3.01,respectively,in lacrimal gland adenoid cystic carcinoma. (P<0.05). Conclusions Schwann’s cell markers GFAP and S-100 in neural invasion group is higher than that in nor-neural invasion group (P<0.05). The Schwann’s cell differentiation may account histologically for the neural invasion of lacrimal gland adenoid cystic carcinoma.
王磊峰,董玉萍,朱素芳,李晓娟,董秋艳,黑砚. 泪腺腺样囊性癌S-100蛋白、神经细丝酸性蛋白的表达及其意义[J]. 武警医学, 2014, 25(12): 1252-1255.
WANG Leifeng, DONG Yuping, ZHU Sufang, LI Xiaojuan, DONG Qiuyan,and HEI Yan. Expression and significance of S-100 and GFAP in lacrimal adenoid cystic carcinoma. Med. J. Chin. Peop. Armed Poli. Forc., 2014, 25(12): 1252-1255.
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2014, Vol. 25 
