Clinical effect of different doses of nebulized budesonide inhalation and intravenous drip of methylprednisolone in treating young children with asthma exacerbations
CHEN Xiaorui and ZHAO Hongxia
CHEN Xiaorui and ZHAO Hongxia. Department of Pediatrics, Shenzhen Maternity and Children Health Care Hospital Affiliated to Suthern Medical University, Shenzhen 518028, China
Abstract：Objective To investigate the clinical effect of different initial doses of nebulized budesonide inhalation and salbutamol and a separate intravenous injection of methylprednisolone in young children with moderate to severe asthma exacerbations. Methods 66 child patients in this hospital suffering from moderate to severe acute asthma were randomly divided into three groups: group A (n=20), group B(n=22) and group C (n=24). Group A were given nebulized budesonide inhalation(0.5 mg each time for under 4 years old, 1mg each time for above 4 years old) and salbutamol(2.5 mg each time) every 8 h for 3 days and then they would be changed to every 12 h. Group B were treated with the same formula as that given to those above 4 years old in group A, with a slight difference in that on the forth day the dose of nebulized budesonide inhalation was reduced to 0.5 mg every 12 h. Group C were given intravenous injection of methylprednisolone, with the formula of 2 mg/kg and every 8 h for 3 d.It would stop using when breathing eased. The clinical symptom scores were made separately at 0, 8, 24, 48 and 72 hours after hospital treatment, blood gas analysis obtained 24 h after treatment, fasting plasma glucose was tested 7 days before and after treatment and adverse reactions were observed. Results Obvious alleviation of acute exacerbation of asthma symptoms was observed among three groups. There was dramatic alleviation occurred in the first 8 h and 24 h for group B/C, and there was statistically significant difference between group A and B/C (P<0.05). But the difference between group B and C was not significant. In 48 h and 72 h after treatment, the difference in score among three groups was not statistically significant. Further, in 24 hours after treatment differences in blood gas analysis among group A and B/C was statistically significant (P<0.05) while the difference in blood gas analysis between group B and C was not statistically significant. For fasting plasma tested after 7 days and before treatment, there was no statistically significant difference in group A and B while there was statistically significant difference in group C (P<0.05). Group C has the highest incidence of adverse reactions, and the difference was statistically significant (P<0.05). Conclusions For moderate to severe acute asthma young children, high initial doses of nebulized budesonide inhalation can control symptoms in short time, reduce the amount of systemic corticosteroid and systemic adverse reactions.
陈晓锐,赵宏霞. 儿童哮喘急性发作布地奈德+沙丁胺醇及甲泼尼龙疗效比较[J]. , 2014, 25(3): 231-234.
CHEN Xiaorui and ZHAO Hongxia. Clinical effect of different doses of nebulized budesonide inhalation and intravenous drip of methylprednisolone in treating young children with asthma exacerbations. , 2014, 25(3): 231-234.
2014, Vol. 25 
