Effect of metoprolol combined with valsartan on hypertensive left ventricular hypertrophy and left ventricular diastolic function
HAN Yanhua1, YANG Chunmei2, SONG Zhonghai1, LI Yubin1, XU Bin1, and LI Qiuying1
1. Department of Special Examination, 2. Department of Cardiology, Hospital of Jilin Provincial Corps, Chinese People’s Armed Police Force, Changchun 130052, China
Abstract：Objective Effect of metoprolol combined with valsartan for treatment of hypertensive patients with left ventricular hypertrophy and left ventricular diastolic function was observed. Methods In this study, we recruited 180 patients diagnosed as having hypertension and left ventricular hypertrophy (LVH) by echocardiographic examination and randomly divided them into three groups, A, B and C. The treatment of the patients in group A was given metoprolol and valsartan; the group B was given valsartan; the group C was given metoprolol; all treatment courses were one year. Echocardiography, 24-hour ambulatory blood pressure, and electrocardiogram were checked, and left ventricular muscle weight and left ventricular mass index were measured. The effects and group differences after and before treatment were compared. Results After treatment, in all patients, blood pressure was well-controlled, left ventricular hypertrophy, left ventricular diastolic function were improved (P<0.01). But group A obtained better efficacy than group B and group C (P<0.01), especially the left ventricular mass index in group A dropped clearly from (136.8±7.3)g/m2 down to (127.7±4.6)g/m2 (P<0.01), the left ventricular diastolic function improved. Conclusions Metoprolol in combination with valsartan to treat hypertension can reduce blood pressure, and left ventricular hypertrophy, and improve left ventricular diastolic function.
韩艳华,杨春梅,宋忠海,栗玉斌,徐斌,李秋颖. 美托洛尔联合缬沙坦对高血压左室肥厚及左室舒张功能的影响[J]. 武警医学, 2015, 26(12): 1234-1236.
HAN Yanhua, YANG Chunmei, SONG Zhonghai, LI Yubin, XU Bin, and LI Qiuying. Effect of metoprolol combined with valsartan on hypertensive left ventricular hypertrophy and left ventricular diastolic function. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(12): 1234-1236.
Roy G C, Sutradhar S R, Barna U K, et al. Cardiovascular complications of chronic renal failure-an updated review [J]. Mymensingh Med J,2012,21(3):573-579.
Roy G C, Sutradhar S R, Barna U K, et al. Cardiovascular complications of chronic renal failure-an updated review [J]. Mymensingh Med J,2012,21(3):573-579.
2015, Vol. 26 
