Diagnostic value of heart-type fatty-acid binding protein in serum for non-ST-elevation acute coronary syndromes
YU Hongbo1, LIU Yang1, LUO Junqing2, LIU Xinguo3, JIAN Ming4, HUANG Meiliang1, LUO Dan1, LI Xuefeng4
1.Department of Clinical Laboratory, 2.Department of Hospital Affairs, 3.Department of Special Examination, 4.Department of Medicine, Hunan Provincial Corps Hospital, Chinese People’s Armed Police Forces, Changsha 410006, China
Abstract：Objective To study the diagnostic value of serum heart-type fatty-acid binding protein(H-FABP)for non-ST-elevation acute coronary syndromes(NSTE ACS). Methods H-FABP and cTnI were measured and compared in 115 NSTE ACS patients and 69 non-cardiac chest pain patients. Results The H-FABP levels were (459±312) pg/ml, (237±169) pg/ml in NSTE ACS group and non-cardiac chest pain group respectively, and there was a significant difference between the two groups(P＜0.05).In NSTE ACS group, the H-FABP level of UAP group was (340±285) pg/ml which was lower than NSTE AMI group (592±289) pg/ml, and there was a significant difference between the two groups(P＜0.05). For the diagnosed NSTE AMI, the area under the ROC curve of H-FABP was 0.863, the sensitivity was 97.1%, specificity was 47.6%; while for the cTnI were 0.799, 61.2%, 93.9%.Conclusions H-FABP is a highly sensitivie marker of the early NSTE ACS and H-FABP detection is conducive to diagnosis of NSTE ACS.
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YU Hongbo, LIU Yang, LUO Junqing, LIU Xinguo, JIAN Ming, HUANG Meiliang, LUO Dan, LI Xuefeng. Diagnostic value of heart-type fatty-acid binding protein in serum for non-ST-elevation acute coronary syndromes. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(2): 133-135.
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2015, Vol. 26 
