1.Department of Cardiology,Beijing Shijitan Hospital Affiliated to the Capital Medical University,Beijing 100038,China; 2.Science School,Communication University of China,Beijing 100024,China
摘要目的 观察他汀类药物在慢性心力衰竭(chronic heart failure,CHF)患者中的应用疗效。方法 选取100例CHF患者,纽约心功能(NYHA)分级Ⅱ至Ⅳ级,左室射血分数(LVEF )≤50%,按照是否使用他汀类药物分为观察组和对照组,每组各50例。观察并比较治疗前后两组左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)、LVEF、C反应蛋白(CRP)、低密度脂蛋白胆固醇(LDL-C)及N末端脑利钠肽前体(NT-proBNP)水平的变化及1年内住院次数及病死率。结果 观察组使用他汀药物治疗后LVESD低于对照组[(50.12±4.67)mm vs (54.89±4.53)mm],LVEDD低于对照组[(65.31±3.82)mm vs (68.59±4.58)mm],LVEF高于对照组[(49.52±4.52)% vs (44.21±5.42)%],差异均有统计学意义(P<0.05)。与治疗前比较,观察组治疗后CRP、LDL-C及NT-proBNP降低(P＜0.05),而对照组无统计学差异。1年内观察组住院次数及病死率均低于对照组,差异有统计学意义(P＜0.05)。结论 以心血管疾病为基础疾病的CHF患者长期使用他汀类药物可明显获益。
Abstract：Objective To evaluate the effect of statins on chronic heant failure (CHF). Methods The clinical data in 100 patients with CHF from this hospital were collected, NYHA ClassⅡ-Ⅳ,and LVEF≤50%.According to whether statins were taken or not, the patients were assigned into two groups,and each group with 50 patients. The levels of left ventriculer end-dimension (LVEDD), left vewtricular end-rystohic climension(LVESD), LVEF, C-reactive protein (CRP), low-density lipoprotein cholesterol (LDL-C), NT-pro BNP, admission times and mortality were compar. Results 1. Compared with the control group, LVESD and LVEDD levels in the statins group significantly decreased (P<0.05), while LVEF was significantly increased(P<0.05).2.In the statins group, the CRP,LDL-C and NT-proBNP was dramatically decreased (P＜0.05),but there were no remarkably changes in control one.3.Admission times and mortality in two groups showed the difference(P<0.05) . Conclusions CHF based on cardiovascular disease with long-term use of statins has obvious benefit.
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Ho J E ,Waters D D,Kean A ,et al .Relation of improvement in estimated glomerular filtration rate with atorvastatin to reductions in hospitalizations for heart failure (from the treating to new targets [TNT] study )[J].Am J Cardiol,2012,109(12):1761-1766.
[6]
Ray J G,Gong Y,Sykora K,et al .Statin use and survival outcomes in elderly patients with heart failure [J].Arch Intern Med ,2005,165(1):62-67.
[7]
Gullestad L,Ueland T,Kjekshus J,et al. Galectin -3 predicts response to statin therapy in the controlled rosuvastatin multinational trial in heart failure (CORONA ) [J].Eur Heart J,2012,33(18):2290-2296.
[8]
Ghio S,Scelsi L,Latini R,et al. Effects of n-3poly unsaturated fatty acids and of rosuvastatin on left ventricular function in chronic heart failure: a substudy of GISSI-HF trial [J]. Eur J Heart Fail,2010,12(12):1345-1353.
[9]
Rhee S H,Kang J,Nahm D S.Cystatins and cathepsin B during orthdortic tooth movement[J].Am J Orthod Dertofacial Orthop,2009,135(1):99-105.
2015, Vol. 26 
