Abstract：Objective To study the effect of tripterygium hypoglaucum hutch combined with hydrochlorothiazide in the treatment of Graves’ ophthalmopathy.Methods 122 patients with Graves’ ophthalmopathy,whose thyroid function had returned to normal and who were taking a maintenance dose of methimazole, were randomly and equally divided into 3 groups. Group A was given routine treatment, group B was given routine treatment plus tripterygium hypoglaucum hutch, and group C was given routine treatment plus tripterygium hypoglaucum hutch and hydrochlorothiazide. The therapeutic effect was analyzed after 3 months.Results The effective rate was 40%(16/40)in group A,70.7%(29/41)in group B,and 85.3%(35/41)in group C. Group B and C were significantly different from group A(P＜0.05),while group B was significantly different from group C(P＜0.05).Conclusions The combination treatment of tripterygium hypoglaucum hutch and hydrochlorothiazide can improve symptoms of Graves’ ophthalmopathy. So this approach can be used for treating Graves’ ophthalmopathy.
段继源, 邵彬, 乔艳艳. 昆明山海棠联合氢氯噻嗪对Graves眼病巩固性治疗效果分析[J]. 武警医学, 2016, 27(12): 1228-1230.
DUAN Jiyuan, SHAO Bin, and QIAO Yanyan. The effect of tripterygium hypoglaucum hutch combined with hydrochlorothiazide in the treatment of Graves’ ophthalmopathy. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(12): 1228-1230.
Hahn E,Laperriere N,Millar B A,et al. Orbital radiation therapy for Graves’ ophthalmopathy: measuring clinical efficacy and impact[J]. Pract Radiat Oncol,2014, 8(4): 233-239.
[2]
葛均波,徐永健.内科学[M].8版.北京: 人民卫生出版社,2013:685-692.
[3]
Jiang X,Huang X C,Ao L, et al. Total alkaloids of Tripterygium hypoglaucum(levl.) Hutch inhibits tumor growth both in vitro and in vivo [J]. J ethnopharmacol,2014,151(1):292-298.
Xu Y,Zheng Y T,He L,et al.Study of Tripterygium hypoglaucum Hutch on mouse’s splenic lymphocyte activation in vitro [J]. Zhong Yao Cai,2008,31(4):557-561.
2016, Vol. 27 
