Abstract：Objective To explore the significance of FOXP1 and Livin expressions in the evaluation of clinicopathological characteristics and prognosis of lymphoma.Methods Eighty patients with diffuse large B cell lymphoma treated at our hospital between August 2013 and August 2015 were selected as observation group, with 40 cases of reactive lymph node hyperplasia patients as control group. The expressions of FOXP1 and Livin in the two groups were observed and analyzed. The relationships between the expressions of FOXP1 and Livin in patients with lymphoma and the clinicopathological features were analyzed.Results The percentage of high expressions of FOXP1 and Livin in the observation group was 77.5% and 60% respectively, which was significantly higher than that in the control group (20%, 5%), and the difference was statistically significant (P<0.05). Among the high-risk IPI and non-GCB patients of lymphoma or those with primary lymphoma, high expression rates of FOXP1 were 92.3%, 86.2%, 86.7% respectively, the proportion was higher, and the difference was statistically significant (P<0.05). In the presence of B-symptom, the expression rates of Livin were 81.2%, 80.8%, 73.3% respectively, the proportion was higher, and the difference was of statistic significance (P<0.05).Conclusions The expression level of FOXP1 and Livin in patients with diffuse large B cell lymphoma is closely related to its clinical features and pathological types.
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2016, Vol. 27 
