Meta-analysis of procalcitonin-guided antibiotics therapy in patients with severe bacterial infection
LI Gang1, XIANG Fang1, and CHEN Zhuo2
1.Hunan Provincial Corps Hospital,Chinese People’s Armed Police Force,Changsha 410006,China; 2.Human Resource Department, General Hospital of the Chinese People’s Armed Police Force,Beijing 100039,China
Abstract：Objective To investigate the effectiveness and safety of procalcitonin-guided therapy in patients with servere infection. Methods Pubmed, Embase and the Cochrane Central Register of Controlled Trials were searched(up to June, 2015).Studies on randomized controlled trials clollected data on all-cause mortality and the duration of antibiotic therapy were included and analysised by Revman 5. Results 8 studies involving 783 patients with PCT guidance treatment and 744 patients with traditional treatment were included.Compared with the control group, with META analysis, researches showed that the duration of antibiotic use was reduced in procalcitonin-guided group (Z=1.08, P=0.28) while the mortality rate of patients was not significantly different between the two groups(Z=0.37, P=0.71). Conclusions Procalcitonin-guided antibiotics therapy in patients with severe bacterial infection can be effective and safe in a shorter duration of antibiotic treatment.
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2016, Vol. 27 
