Association of polymorphisms in promoter region of tumor necrosis factor and interleukin 6 gene with major depressive disorder
MA Xinhui1,FU Yu1,CAO Shujie2,WANG Shuangli1,WU Weijing1,WANG Junli1, and WANG Fang1
1.Department of Clinical Laboratory,Heilongjiang Provincial Corps Hospital, Chinese People’s Armed Police Force, Harbin 150076, China; 2. Department of Clinical Laboratory,The First Specialist Hospital of Harbin in Heilongjiang Province,Harbin 150001, China
Abstract：Objective To investigate the relationship between the -308G/A and -857C/T of tumor necrosis factorαgene(TNF-α),-174G/C and-572C/G of interleukin-6 gene(IL-6)polymorphisms and major depressive disorder.Methods Genomic DNA was isolated from the venous blood leukocytes of 393 unrelated patients with major depressive disorder and 393 healthy unrelated individuals(control group).All of the polymorphisms were genotyped by PCR-restriction fragment length polymorphisms (PCR-RFLP).Genotype and allele frequencies were analyzed using SPSS 13.0 software. Results There were significant differences in both allele and genotype frequencies of -857C/T of TNF-αgene between the major depressive disorder and control groups(P<0.05).The allele T of -857 T in male major depressive disorder group was significantly higher than that in contol group(OR=0.309,95% CI:0.218-0.439, P<0.01) The allele A of -308 A in female major depressive disorder group was significantly higher than that in contol group (OR=0.399,95% CI:0.246-0.648, P<0.01). Conclusions This study confirm that TNF-α gene promoter region gene polymorphism may be risk factors for severe depressive disorder in North China Han.TNF-α gene promoter polymorphism may be associated with the onset of severe depressive disorder.
马心慧, 付瑜, 曹淑杰, 王双力, 武伟晶, 王军利, 王芳. 重度抑郁障碍与肿瘤坏死因子ɑ和白细胞介素6基因启动子区多态性的相关性[J]. 武警医学, 2016, 27(3): 259-262.
MA Xinhui,FU Yu,CAO Shujie,WANG Shuangli,WU Weijing,WANG Junli, and WANG Fang. Association of polymorphisms in promoter region of tumor necrosis factor and interleukin 6 gene with major depressive disorder. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(3): 259-262.
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