1.Current Master Degree Students of Logistics University of People’s Armed Police Force, Tianjin 300309 , China. 2. Department of Scientific Research Office; 3.Department of Medical Experimental Center; 4. Department of MRI Center; 5.Department of Oltrasoun, 6.Department of Ophthalmology,7.Department of Orthopeadics, General Hospital of Chinese People’s Armed Police Force,Beijing 100039 , China
Abstract：Objective To verify the feasibility of optical coherence tomography(OCT) for thickness measurement of rabbit knee joint cartilage as a non-invasive measurement method via comparing with 3.0 T MRI and ultrasonic pachymetry. Methods 40 standardized culturea, adult and male New Zealand white rabbits were recruited for this study(80 knees). Ultrafine probe was used to mark measurement point. Using OCT, 3.0 T MRI and ultrasonic techniques, cartilage thickness data were obtained at the same point,respectively. The difference between OCT and the other two methods was compared. Results The numerical results of OCT, 3.0 T MRI, ultrasonic pachymetry measurement method of cartilage thickness were(0.31±0.03)mm,(0.30±0.05)mm,(0.33±0.06)mm,respectively, without statistically significant difference (OCT- ultrasonic t=1.995,P=0.051,OCT-MRI t=1.955,P=0.054). And the time required were(2.5±0.3)min、(6.3±0.7)min、(3.3±0.6)min, respectively. The accuracy of the three measuring methods were 0.001 mm, 0.01 mm and 0.01 mm. Conclusions Compared with 3.0 TMRI and ultrasonic pachymetry, OCT measurement of rabbit knee joint cartilage thickness has the advantages of precision, time-saving, good repeatability, low cost ,and human error small, worthy of animal experimental practice.
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2016, Vol. 27 
