Preliminary study on effectiveness of the LAMaxTM plus left atrial appendage occluder specially designed for left atrial appendage with two lobes and a wider orifice in canine model
MENG Yuezhi1, WU Xiaoxia2, WANG Xifu3, CHEN Yilong4,5, HUANG Wei5,6, and MA Dongxing1
1.Department of Cardiology, the Clinical College of the General Hospital of Chinese People’s Armed Police Force, Anhui Medical University, Hefei 230032, China; 2.Department of Ultrasonography, The General Hospital of Chinese People’s Armed Police Force, Beijing, 100039, China; 3. Emergency Critical Care Center, Anzhen Hospital, Capital Medical University, Beijing 100029, China; 4.Shenzhen Ke Yi Dun Biomedical Technology Co. Ltd., Shenzhen 518110, China; 5.Peking University Shenzhen Research Institute, Shenzhen, 518057, China; 6.Department of Mechanical and Aerospace Engineering, Hong Kong University of Science and Technology, Hong Kong SAR, China
Abstract：Objective To demonstrate the feasibility and effectiveness of a left atrial appendage (LAA) occluder (LAMaxTM plus,Keyidun,China) for the instant occlusion of LAA in canine model, which is specially designed for the occlusion of LAA with two lobes and a wider orifice.Methods Three healthy dogs were used for the implantation of LAMaxTM plus devices, which can be fully recaptured and repositioned during implantation procedure. Before the implantation, transthoracic echocardiography (TTE) was performed for anatomical evaluation of LAA with two lobes and then transesophageal echocardiography (TEE) followed by angiography. The devices were delivered by 9F or 10F delivery sheathes. The angiography of LAA was performed immediately after the implantation and then TEE examination followed to evaluate the device position, leakage around the device, pericardial effusion, mitral valve function, and pulmonary vein obstruction. The effectiveness of LAA occlusion was assessed by an endpoint of leak around the device less than 3mm of flow by TEE.Results The LAMaxTM plus was successfully implanted in all three dogs. By observation of the post-implant TEE, all dogs reached the defined endpoint for the effectiveness of LAA occlusion.Conclusions This preliminary study confirms that LAMaxTM plus device is feasible and effective for the instant occlusion of LAA with two lobes in canines. More studies are needed before it can be used in clinical applications.
孟越之，吴晓霞，王喜福，陈奕龙，黄 伟，马东星. LAMaxTM plus左心耳封堵器封堵犬双叶宽开口左心耳的可行性和即刻有效性[J]. 武警医学, 2016, 27(6): 589-592.
MENG Yuezhi, WU Xiaoxia, WANG Xifu, CHEN Yilong, HUANG Wei, and MA Dongxing. Preliminary study on effectiveness of the LAMaxTM plus left atrial appendage occluder specially designed for left atrial appendage with two lobes and a wider orifice in canine model. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(6): 589-592.
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