Association between severe preeclampsia and mononmine oxidase A gene
SUN Yan1, HOU Xuejing1,and GUO Hongmei2
1.Department of Obstetrics, The First Hospital of Qinhuangdao, Qinhuangdao 066000, China; 2.Department of Stomatology, General Hospital of Chinese People’s Armed Police Force,Beijing 100039,China
Abstract：Objective To analyze the impact of this polymorphism of monoamine oxidase A(MAO-A) variable number tandem repeat (VNTR) on the risk of severe preeclampsia.Methods Sixty pregnant women wih severe preeclampsia and seventy normal pregnant women were genotyped for MAO-A VNTR polymorphism using PCR-based restriction fragment length polymorphism method.Results Significant differences were not observed between the case group and normal controls in the frequencies of MAO-A VNTR alleles and genotypes.Conclusions There is no significant difference in the allele and genotype frequencies of MAO-A gene between case group and normal controls . Our results show that MAO-A VNTR polymorphism perhaps can no increase the risk of severe preeclampsia.
孙 燕，侯雪晶，郭红梅. 单胺氧化酶A基因启动子30-bp重复序列多态性与重度子痫前期发病机制的关系[J]. 武警医学, 2016, 27(7): 724-726.
SUN Yan, HOU Xuejing,and GUO Hongmei. Association between severe preeclampsia and mononmine oxidase A gene. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(7): 724-726.
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2016, Vol. 27 
