Protective effect of vitamin E combined with Radix astragali on skeletal muscle injury caused by march
SI Ying1 and TAI He2
1.Dalian Branch of Liaoning Provincial Corps Hospital, Chinese People’s Armed Police Force, Dalian 116013, China; 2. Department of Serviceman, Liaoning Provincial Corps Hospital, Chinese People’s Armed Police Force, Shenyang 110034, China
Abstract：Objective To observe the change in muscle injury caused by march, investigate the protective effect of vitamin E combined with Radix astragali on skeletal muscle injury caused by violent exercise. Methods Sixty recruits were randomly divided into three groups (20 solders in each group). Group A (control group), group B (given vitamin E), group C (given vitamin E and Radix astragali). Group B was given vitamin E [8 mg/(kg·d)] for 14 days and group C was given vitamin E [8 mg/(kg·d)] +Radix astragali (15 g/d) for 14 days. Then they marched 120 km for 4 days. The recruits were given fomentation and massage (20 min once, twice/day) in leg in 3 groups. The oxydic and antioxidant indices and CK, LDH were detected in 2 h, 3 h, 6 h and 24 h after march in the three groups. Results The activity of CK, LDH, ROS and the concentration of MDA in group A all time points were higher than that in the other two groups (P＜0.05) after march, while the GSHG-Px and SOD at all time points were lower than those in the other two groups at all time points (P＜0.05) after march. The activities of CK, LDH, ROS and the concentration of MDA in group B at all time points were higher than in the group C (P＜0.05), while the GSHG-Px, SOD at all time points were lower than in the group C at all time points (P＜0.05). The activities of GSH-Px and SOD were reduced after march, reaching minimum at 6 h, and increased at 24 h in the 3 groups (P＜0.05). The activities of ROS, LDH, ROS and the concentration of MDA increased after march, peaked at 6 h after march, and decreased at 24 h after march in the 3 groups (P＜0.05). Conclusions Vitamin E combined with Radix astragali can inhibit muscle injury in the course of long-time movement through balancing oxidation and antioxidation. This method is safe and effective, it should be recommended to grass-roots units.
司迎, 邰贺. 维生素E联合黄芪对新兵新训期间徒步行军后骨骼肌损伤的保护作用[J]. 武警医学, 2016, 27(9): 932-935.
SI Ying and TAI He. Protective effect of vitamin E combined with Radix astragali on skeletal muscle injury caused by march. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(9): 932-935.
2016, Vol. 27 
