1.Department of Neurosurgery,General Hospital of Chinese People’s Armed Police Force,Beijing 100039,China; 2.Department of Neurosurgery,Tiantan Hospital Attached to Capital Medical University,Beijing 100050,China
Abstract：Objective To explore the therapeutic effect of microsurgical methods on craniopharyngioma.Methods The clinical data of 136 cases of patients with craniopharyngioma treated in our hospital between January 2010 and December 2014 were retrospectively analyzed. Operations were performed under the microscope. The the fronto basal interhemispheric approch was adopted in 42 cases,subfrontal approach in 28 cases, callosal interforniceal approach in 27 cases, pterional approach in 36 cases, and the transsphenoidal approach in 3 cases.Results Total tumor removal was achieved in 118 cases, subtotal removal in 14 cases, and partial removal in 4 cases. Also, there were 63 cases of postoperative diabetes insipidus (temporary diabetes insipidus in 42 cases),and 28 cases of decreased vision or blindness. Electrolyte disorders occurred in 65 cases. As for other complications, there were 8 cases of central high fever, 3 cases of oculomotor nerve injury, 1 case of cerebral infarction, 2 cases of intracranial infection. And 3 cases of death one month after operation. There were also 3 cases of automatic discharge, who gave up treatment because of the severity of illness or for financial reasons.Conclusions Selection of an appropriate surgical approach based on the location and growth mode of the craniopharyngioma is the key to the success of surgical treatment.
Yasargil M G,Curcic M,Kis M,et al.Total removal of craniopharyngiomas.Approaches and longterm results in 144 patients[J].J Neurosurg,1990,73(1):3-11.
[6]
Vinchon M,Dhellemmes P.Craniopharyngiomas in children: recurrence,reoperation and outcome[J].Childs Nerv Syst,2008,24(2):211-217.
[7]
Shi X E,Wu B,Fan T,et al.Craniopharyngioma:Surgical experience of 309 cases in China[J].Clin Neurol Neuro-surg,2008,110(2):151-159.
[8]
Kawamata T,Amano K,Aihara Y,et al. Optimal treatment strategy for craniopharyngiomas based on long-term functional outcomes of recent and past treatment modalities[J].Neurosurg Rev,2010,33(1):71-81.
[9]
Komotar R J,Roguski M,Bruce J N.Surgical management of craniopharyngiomas[J].J Neurooncol,2009,92(3):283-296.
Hassaneen W,Suki D,Salaskar A L,et al.Immediate morbidity and mortality associated with transcallosal resection of tumors of the third ventricle[J].J Clin Neuro-sci,2010,17(7):830-836.
[14]
Frank G,Pasquini E,Doglietto F,et al.The endoscopic extended transsphenoidal approach for craniopharyngiomas[J].Neurosurgery,2006,59(1 Suppl 1):75-83.
Chakrabarti I,Amar A P,Couldwell W,et al.Long-term neurological,visual,and endocrine outcomes following transnasal resection of craniopharyngioma[J].J Neurosurg,2005,102(4):650-657.
2017, Vol. 28 
