Distribution of pathogens for hospital acquired pneumonia and drug resistance analysis of gram-negative bacteria
LI Bei1, LUO Wenling2, XIE Xiaoyue1, HUANG Ligang3, YAN Feng2
1. Infection Office, First Hospital of Tsinghua University, Beijing 100016, China; 2. Department of Respiration, First Hospital of Tsinghua University, Beijing 100016, China; 3. Division of Clinical Laboratory, First Hospital of Tsinghua University, Beijing 100016, China
Abstract：Objective To analyze both the distribution of pathogens that cause hospital acquired pneumonia and drug resistance of gram-negative bacteria in a hospital. Methods Pathogens of hospital-acquired pneumonia were collected from 2012 to 2016. The drug resistance of gram-negative bacteria was detected with MIC and evaluated according to the criteria of Clinical and Laboratory Standard Institute of America (CLSI). Results Among these pathogens of hospital-acquired pneumonia, gram-negative bacteria were common and the top three organisms were Pseudomonas aeruginosa, Klebsiella pneumoniae, and Baumanii, accounting for 17.38%, 17.30%, and 15.98%, respectively. Among gram-positive bacteria, Staphylococcys aureus was common. In these pathogens, fungus accounted for 12% to 15% of acquired respiratory tract infections.Pseudomonas aeruginosa was the most sensitive to amikacin (87.76%-95.56%). The sensitivity of Klebsiella pneumoniae to meropenem and imipenem decreased year by year.The sensitivity of Baumanii to other antimicrobial agents was low except amikacin (63.64%-84.78%). Conclusions The detection rate of multi-drug resistance of Pseudomonas aeruginosa and Baumanii is beginning to decrease significantly. Klebsiella pneumoniae, which produces ESBL and carbon-resistant penicillium, is worthy of attention. Regular and prudent surveillance of the distribution of pathogens responsible for hospital acquired pneumonia and drug resistance can help clinicians to treat and prevent HAP.
李蓓, 骆文玲, 解晓悦, 黄立纲, 延峰. 2012-2016年本医院内获得性肺炎病原菌分布及革兰阴性杆菌耐药性分析[J]. 武警医学, 2017, 28(11): 1151-1154.
LI Bei, LUO Wenling, XIE Xiaoyue, HUANG Ligang, YAN Feng. Distribution of pathogens for hospital acquired pneumonia and drug resistance analysis of gram-negative bacteria. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(11): 1151-1154.
Plagov A, Mejias L, Piazza Y, et al . Validation of Beckman Coulter AU680 Analyzers: Utility of Clinical Laboratory Standards Institute (CLSI) C28~A3[J]. Am J Clin Pathol, 2014, 142(suppl_1): A042-A042.
2017, Vol. 28 
