Abstract：Objective To study the risk factors of acute cerebral infarction in patients with leukoaraiosis (LA) and without leukoaraiosis (LA), and to explore the possible risk factors of LA.Methods Two hundred and seven patients of acute cerebral infarction, with or without LA, were divided into LA group (n=93) and non-LA group (n= 114).Clinical data was collected on age, hypertension, cerebral infarction, HCY, hsCRP, sex, smoking history, drinking history, diabetes, hyperlipidemia, and coronary heart disease of these patients. Logistic single-factor and multi-factor regression analysis was used to identify the risk factors.Results (1) Single-factor analysis suggested that there was statistically significant difference between LA group and non-LA group in age, hypertension, cerebral infarction, HCY and hsCRP (P<0.05), but not in gender, smoking history, drinking history, diabetes, hyperlipidemia or coronary heart disease. (2) Multivariate logistic regression analysis indicated that age, hypertension, history of cerebral infarction, HCY and hsCRP were risk factors of LA (P<0.05).Conclusions Age, hypertension, cerebral infarction, HCY and hsCRP are possibly associated with leukoaraiosis.
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